Regardless of the origin, injury to the heart can result in cardiomyocyte hypertrophy, fibrosis,
and cell death. Myocarditis often progresses to dilated cardiomyopathy (DCM), a major …

Background: Myocarditis is a life-threatening heart disease characterized by myocardial
inflammation, necrosis, and chronic fibrosis. While mast cell inhibition has been suggested …

Autoimmune responses and inflammation are involved in the pathogenesis of many
cardiovascular diseases. There is compelling evidence that inflammatory mechanisms may …

Recent recognition that an autoimmune myocarditis may precede, and result in, dilated
cardiomyopathy has focused attention on immune mechanisms of myocardial injury. In this …

Background Myocarditis, characterized by myocyte necrosis, fibrosis, and degeneration with
mononuclear cell infiltration, always causes heart failure in patients. Phosphoinositide 3 …

Serial technetium-99m radionuclide ventriculograms, indium-111 antimyosin antibody scans
and tissue biodistribution studies were performed in C, H/He mice with experimentally …

LB Stull, NA DiIulio, M. Yu, CF McTiernan, NB Ratliff, VK Tuohy and C. Schomisch Moravec.
Alterations in Cardiac Function and Gene Expression during Autoimmune Myocarditis in …

Background Matrix metalloproteinase (MMP) activity is upregulated in the hearts with
myocarditis, and its activation contributes to the changes in left ventricular function. A major …

Myocarditis is an acute inflammatory disease of the heart and a precursor of dilated
cardiomyopathy. 1–8 Myocarditis is often characterized by a cellular infiltrate, and if …

ABSTRACT Background and Objectives: Myocarditis is a potentially fatal disease, but
curative treatments have not yet been established. Myocardial inflammation is an important …