[HTML][HTML] CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis
Abstract Background Extracellular vesicles (EVs) released by neurons and glia reach the
cerebrospinal fluid (CSF). Studying the proteome of CSF-derived EVs offers a novel …
cerebrospinal fluid (CSF). Studying the proteome of CSF-derived EVs offers a novel …
[HTML][HTML] Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis
L Pasetto, S Callegaro, A Corbelli, F Fiordaliso… - Molecular …, 2021 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem motor neuron
disease for which currently there is no effective treatment. There is an urgent need to identify …
disease for which currently there is no effective treatment. There is an urgent need to identify …
[HTML][HTML] Revealing the proteome of motor cortex derived extracellular vesicles isolated from amyotrophic lateral sclerosis human postmortem tissues
N Vassileff, LJ Vella, H Rajapaksha, M Shambrook… - Cells, 2020 - mdpi.com
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the
deposition of misfolded proteins in the motor cortex and motor neurons. Although a multitude …
deposition of misfolded proteins in the motor cortex and motor neurons. Although a multitude …
[HTML][HTML] Extracellular vesicles and amyotrophic lateral sclerosis: from misfolded protein vehicles to promising clinical biomarkers
D Gagliardi, N Bresolin, GP Comi, S Corti - Cellular and Molecular Life …, 2021 - Springer
Extracellular vesicles (EVs) are small reservoirs of different molecules and important
mediators of cell-to-cell communication. As putative vehicles of misfolded protein …
mediators of cell-to-cell communication. As putative vehicles of misfolded protein …
[HTML][HTML] Extracellular vesicles as potential biomarkers in amyotrophic lateral sclerosis
M Barbo, M Ravnik-Glavač - Genes, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is described as a fatal and rapidly progressive
neurodegenerative disorder caused by the degeneration of upper motor neurons in the …
neurodegenerative disorder caused by the degeneration of upper motor neurons in the …
[HTML][HTML] Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS
A Varcianna, MA Myszczynska, LM Castelli, B O'Neill… - …, 2019 - thelancet.com
Background Astrocytes regulate neuronal function, synaptic formation and maintenance
partly through secreted extracellular vesicles (EVs). In amyotrophic lateral sclerosis (ALS) …
partly through secreted extracellular vesicles (EVs). In amyotrophic lateral sclerosis (ALS) …
[HTML][HTML] Pathological proteins are transported by extracellular vesicles of sporadic amyotrophic lateral sclerosis patients
D Sproviero, S La Salvia, M Giannini… - Frontiers in …, 2018 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive adult-onset neurodegenerative disease,
that affects cortical, bulbar and spinal motor neurons, and it is considered a proteinopathy, in …
that affects cortical, bulbar and spinal motor neurons, and it is considered a proteinopathy, in …
[HTML][HTML] Recent advances in extracellular vesicles in amyotrophic lateral sclerosis and emergent perspectives
GJM Afonso, C Cavaleiro, J Valero, SI Mota, E Ferreiro - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease
characterized by the progressive death of motor neurons, leading to paralysis and death. It is …
characterized by the progressive death of motor neurons, leading to paralysis and death. It is …
Cerebrospinal fluid extracellular vesicle enrichment for protein biomarker discovery in neurological disease; multiple sclerosis
The discovery of disease biomarkers, along with the use of “liquid biopsies” as a minimally
invasive source of biomarkers, continues to be of great interest. In inflammatory diseases of …
invasive source of biomarkers, continues to be of great interest. In inflammatory diseases of …
[HTML][HTML] Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid
K Otake, H Kamiguchi, Y Hirozane - BMC medical genomics, 2019 - Springer
Background Exosomes are a subset of extracellular vesicles 30–200 nm in diameter
secreted from cells, which contain functional mRNAs and microRNAs. Cerebrospinal fluid …
secreted from cells, which contain functional mRNAs and microRNAs. Cerebrospinal fluid …