In vitro inhibition and induction of human liver cytochrome P450 enzymes by gentiopicroside: potent effect on CYP2A6

Y Deng, L Wang, Y Yang, W Sun, R Xie, X Liu… - Drug Metabolism and …, 2013 - Elsevier
Gentiopicroside (GE), a naturally occurring iridoid glycoside, has been developed into a
Novel Traditional Chinese Drug named gentiopicroside injection, and it was approved for …

Modulation of cytochrome P-450-dependent monooxygenases, glutathione and glutathione S-transferase in rat liver by geniposide from Gardenia jasminoides

JJ Kang, HW Wang, TY Liu, YC Chen… - Food and chemical …, 1997 - Elsevier
Geniposide is an iridoid glycoside extracted from the fruits of Gardenia jasminoides, which
are used as a food colorant and as a traditional Chinese medicine for treatment of hepatic …

Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method

J Gao, Y Zhang, X Lei, Y Xu, Z Sun, X Wang - Toxicology in Vitro, 2022 - Elsevier
Hydroxygenkwanin (HGK), a natural flavonoid extracted from the buds of Daphne genkwa
Sieb. et Zucc.(Thymelaeaceae), possesses a wide range of pharmacological activities …

Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes

SF Zhou, Y Deng, H Bi, L Zhao, X Wang… - Drug Metabolism …, 2008 - ingentaconnect.com
Ginkgo biloba is one of the most popular herbal medicines in the world, due to its purported
pharmacological effects, including memory-enhancing, cognition-improving, and antiplatelet …

In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450

T Winitthana, N Niwattisaiwong, C Patarapanich… - Toxicology in vitro, 2011 - Elsevier
The inhibitory effects and types of inhibition of asiaticoside and madecassoside on human
CYPs were studied in vitro using recombinant human CYPs. The median inhibitory …

(R)-(+)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 2A6

SC Khojasteh-Bakht, LL Koenigs, RM Peter… - Drug metabolism and …, 1998 - ASPET
(R)-(+)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome
P450 (CYP or P450) 2A6. Menthofuran caused a time-and concentration-dependent loss of …

In vitro inhibitory effects of kaempferitrin on human liver cytochrome P450 enzymes

N Zhang, J Liu, Z Chen, W Dou - Pharmaceutical biology, 2019 - Taylor & Francis
Context: Kaempferitrinis (KF) is a bioactive flavonoid and possesses numerous
pharmacological activities. However, whether KF affects the activity of human liver …

In vitro effect of important herbal active constituents on human cytochrome P450 1A2 (CYP1A2) activity

Y Pan, KH Tiong, BA Abd-Rashid, Z Ismail, R Ismail… - Phytomedicine, 2014 - Elsevier
This study was designed to investigate eight herbal active constituents (andrographolide,
asiaticoside, asiatic acid, madecassic acid, eupatorin, sinensetin, caffeic acid, and …

Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats

Y Deng, HC Bi, LZ Zhao, F He, YQ Liu, JJ Yu, ZM Ou… - Xenobiotica, 2008 - Taylor & Francis
1. Ginkgo biloba is one of the most popular herbal medicines worldwide due to its memory-
enhancing and cognition-improving effects. The current study was designed to investigate …

Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities

M Kopečná-Zapletalová, K Krasulová… - Xenobiotica, 2017 - Taylor & Francis
The possibility of interaction of isoflavonoids with concomitantly taken drugs to determined
isoflavonoids safety was studied. Inhibition of nine forms of cytochrome P450 (CYP3A4 …