The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …

Organisms have developed several DNA‐repair pathways as well as DNA‐damage
checkpoints to cope with the frequent challenge of endogenous and exogenous DNA …

▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to
mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular …

DNA is subjected to several modifications, resulting from endogenous and exogenous
sources. The cell has developed a network of complementary DNA-repair mechanisms, and …

Cellular genomes are vulnerable to an array of DNA-damaging agents, of both endogenous
and environmental origin. Such damage occurs at a frequency too high to be compatible …

DNA repair systems are essential for the maintenance of genome integrity. Consequently,
the disregulation of repair genes can be expected to be associated with significant …

Cellular DNA-repair pathways involve proteins that have roles in other DNA-metabolic
processes, as well as those that are dedicated to damage removal. Several proteins, which …

The field of DNA damage responsiveness in general, and the consequences of endogenous
and exogenous base damage in DNA, in particular, has made new and exciting …

REPAIRtoire is the first comprehensive database resource for systems biology of DNA
damage and repair. The database collects and organizes the following types of …

DNA damage has been long recognized as causal factor for cancer development. When
erroneous DNA repair leads to mutations or chromosomal aberrations affecting oncogenes …