Background: Cognitive functions progressively deteriorate during aging and
neurodegenerative diseases. The present study aims at investigating differences in working …

In recent years, several theories have been proposed in attempts to identify the neural
mechanisms underlying successful cognitive aging. Old subjects show increased neural …

Cross-sectional research has shown that older adults tend to have different frontal cortex
activation patterns, poorer brain structure, and lower task performance than younger adults …

We explored the effects of aging on 2 large-scale brain networks, the default mode network
(DMN) and the task-positive network (TPN). During functional magnetic resonance imaging …

The effects of age on functional connectivity (FC) of intrinsic connectivity networks (ICNs)
have largely been derived from cross-sectional studies. Far less is known about longitudinal …

Introduction Rapidly increasing aging of the world's population is causing a heightened
prevalence of Alzheimer's disease (AD) and mild cognitive impairment (MCI). The global …

Aging leads to global changes in brain structure and cognitive performance, with
reorganization of functional brain networks. Importantly, these age-related changes show …

Recent research has shown that the Default Mode Network (DMN) typically exhibits
increased activation during processing of social and personal information but shows …

Centenarians without dementia can be considered as a model of successful ageing and
resistance against age-related cognitive decline. Is there something special about their brain …

Background/Objective: Healthy aging may be accompanied by some types of cognitive
impairment; moreover, normal aging may cause natural atrophy in the healthy human brain …