The initiation of cell division integrates a large number of intra-and extracellular inputs. D-
type cyclins (hereafter, cyclin D) couple these inputs to the initiation of DNA replication …

D-type cyclins are central regulators of the cell division cycle and are among the most
frequently deregulated therapeutic targets in human cancer, but the mechanisms that …

Mammalian development, adult tissue homeostasis and the avoidance of severe diseases
including cancer require a properly orchestrated cell cycle, as well as error-free genome …

In mammalian somatic-cell cycles, progression through the G1-phase restriction point and
initiation of DNA replication are controlled by the ability of the retinoblastoma tumour …

Oscillations in cyclin-dependent kinase (CDK) activity drive the somatic cell cycle. After entry
into mitosis, CDKs activate the anaphase-promoting complex (APC), which then promotes …

The spindle checkpoint prevents chromosome mis-segregation by delaying sister chromatid
separation until all chromosomes have achieved bipolar attachment to the mitotic spindle. Its …

The entry of mammalian cells into the DNA synthesis phase (S phase) represents a key
event in cell division. According to current models of the cell cycle, the kinase CDC7 …

Cyclin degradation is central to regulation of the cell cycle. Mitotic exit was proposed to
require degradation of the S phase cyclin Clb5 by the anaphase-promoting complex …

In mammalian cells, the decision to proliferate is thought to be irreversibly made at the
restriction point of the cell cycle,, when mitogen signalling engages a positive feedback loop …

Cyclin D1 is a component of the core cell cycle machinery. Abnormally high levels of cyclin
D1 are detected in many human cancer types. To elucidate the molecular functions of cyclin …