Redox regulation of the transcriptional repressor Bach1
M Ishikawa, S Numazawa, T Yoshida - Free Radical Biology and Medicine, 2005 - Elsevier
Bach1 is a transcriptional repressor of heme oxygenase-1, one of the most inducible phase
2 proteins. Bach1 binds in conjunction with a small Maf protein to tandem repeats of the …
2 proteins. Bach1 binds in conjunction with a small Maf protein to tandem repeats of the …
Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1
JF Reichard, GT Motz, A Puga - Nucleic acids research, 2007 - academic.oup.com
Oxidative stress activates the transcription factor NRF2, which in turn binds cis-acting
antioxidant response element (ARE) enhancers and induces expression of protective …
antioxidant response element (ARE) enhancers and induces expression of protective …
[HTML][HTML] The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle
The regulation of gene expression in response to environmental signals and metabolic
imbalances is a key step in maintaining cellular homeostasis. BTB and CNC homology 1 …
imbalances is a key step in maintaining cellular homeostasis. BTB and CNC homology 1 …
[HTML][HTML] Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene
J Sun, H Hoshino, K Takaku, O Nakajima, A Muto… - The EMBO …, 2002 - embopress.org
Abstract Heme oxygenase‐1 (HO‐1) protects cells from various insults including oxidative
stress. Transcriptional activators, including the Nrf2/Maf heterodimer, have been the focus of …
stress. Transcriptional activators, including the Nrf2/Maf heterodimer, have been the focus of …
Novel insights into the regulation of antioxidant-response-elementmediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by …
HK Jyrkkänen, S Kuosmanen, M Heinäniemi… - Biochemical …, 2011 - portlandpress.com
A central mechanism in cellular defence against oxidative or electrophilic stress is mediated
by transcriptional induction of genes via the ARE (antioxidant-response element), a cis …
by transcriptional induction of genes via the ARE (antioxidant-response element), a cis …
Expression of the Oxidative Stress-Regulated Transcription Factor Bach 2 in Differentiating Neuronal Cells
H Hoshino, K Igarashi - The Journal of Biochemistry, 2002 - jstage.jst.go.jp
Bach2 is an oxidative stress-regulated transcription factor and functions as a repressor of
gene expression directed by the TPA-response element, the Maf recognition element, and …
gene expression directed by the TPA-response element, the Maf recognition element, and …
[HTML][HTML] Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, β-globin …
KJ Hintze, Y Katoh, K Igarashi, EC Theil - Journal of biological chemistry, 2007 - ASBMB
Ferritin gene transcription is regulated by heme as is ferritin mRNA translation, which is
mediated by the well studied mRNA· IRE/IRP protein complex. The heme-sensitive DNA …
mediated by the well studied mRNA· IRE/IRP protein complex. The heme-sensitive DNA …
[HTML][HTML] Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells
T Kitamuro, K Takahashi, K Ogawa… - Journal of Biological …, 2003 - ASBMB
Heme oxygenase 1 (HO-1) catalyzes heme breakdown, eventually releasing iron, carbon
monoxide, and bilirubin IXα. HO-1 is induced by its substrate heme and various …
monoxide, and bilirubin IXα. HO-1 is induced by its substrate heme and various …
[HTML][HTML] BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite
JF Reichard, MA Sartor, A Puga - Journal of biological chemistry, 2008 - ASBMB
Intracellular heme is a redox active molecule that can be detrimental to cells at high
concentrations or under oxidizing conditions. To prevent accumulation, the inducible …
concentrations or under oxidizing conditions. To prevent accumulation, the inducible …
[HTML][HTML] Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS
Y Shan, RW Lambrecht, T Ghaziani… - Journal of Biological …, 2004 - ASBMB
Heme oxygenase-1 is an antioxidant defense enzyme that converts heme to biliverdin, iron,
and carbon monoxide. Bach-1 is a bZip protein that forms heterodimers with small Maf …
and carbon monoxide. Bach-1 is a bZip protein that forms heterodimers with small Maf …