Up-regulation of heme oxygenase 1 (HO-1) by ultraviolet A (UVA; 320–380nm) irradiation of
human skin cells protects them against oxidative stress. The role of Nrf2 in up-regulation of …

Antioxidants cause stabilization and nuclear translocation of NF-E2-related factor 2 (Nrf2),
where it binds to the antioxidant response element (ARE) and induces up-regulation of …

The antioxidant response element (ARE) and Nrf2 are known to regulate the expression and
coordinated induction of genes encoding detoxifying enzymes including NAD (P) H: quinone …

The transcription repressor Bach1 is a sensor and effector of heme that regulates the
expression of heme oxygenase 1 and globin genes. Heme binds to Bach1, inhibiting its …

Oxidative stress is generated by reactive oxygen species (ROS) produced in response to
metabolic activity and environmental factors. Increased oxidative stress is associated with …

Recent investigations into the regulation of heme oxygenase-1 gene (hmox-1) transcription
have exposed mechanisms of increasing diversity and complexity worthy of a gene whose …

The antioxidant response element (ARE) mediates the transcriptional activation of many
genes encoding phase II drug-metabolizing enzymes in response to oxidative stress. Recent …

The mammalian transcription factor Bach1 functions as a repressor of the enhancers of
heme oxygenase‐1 (HO‐1) gene (Hmox‐1) by forming heterodimers with the small Maf …

Heme—as a prosthetic group of proteins required for oxygen transport and storage,
respiration, and biosynthetic pathways—is essential for practically all forms of life …

Transforming growth factor-β (TGF-β) has multiple functions in embryogenesis, adult
homeostasis, tissue repair, and development of cancer. Here, we report that TGF-β …