Mucopermeating nanocargoes being able to overcome mucosal, as well as extracellular
barrier leads to enhance penetration of poorly soluble anticancer drugs at its target site. We …

Purpose Polymeric micelles are attractive nanocarriers for tumor-targeted delivery of
paclitaxel (PTX). High antitumor efficacy and low toxicity require that PTX mainly …

P-glycoprotein (P-gP) efflux-mediated multidrug resistance is a fundamental aspect of
chemotherapeutic failure in oncology. The current study aims to deliver paclitaxel (PTX) …

This study presents the combination of the prodrug approach with the self-assembly
technique by using a poly (ethylene glycol)–paclitaxel (PTX) conjugate as the nanomicellar …

We describe the development and evaluation of a hybrid lipopolymeric system comprising
carboxymethyl chitosan (CMC), covalently tethered to phosphatidylethanolamine units on …

Abstract Paclitaxel (PTX), especially albumin-bound PTX in clinical, has displayed
significant inhibition of tumor growth in patients. But the systemic distribution and poor water …

Treatment of cancer patients with taxane-based chemotherapeutics, such as paclitaxel
(PTX), is complicated by their narrow therapeutic index. Polymeric micelles are attractive …

Endosomal pH-responsive micellar nanoparticles were prepared by self-assembly of an
amphiphilic poly (ethylene glycol)-acetal-paclitaxel (PEG-acetal-PTX) prodrug, and free PTX …

Nanoscale polymeric micelles have promising applications as drug delivery systems (DDS).
In this work, to improve the anti-tumor activity and eliminate toxicity of the commercial …

This study was aimed at fabricating tumor targeting and acid-responsive micelles as carriers
for paclitaxel (PTX). An amphipathic polymer TOS-Ace-PEG-Bio was designed and …