Aims The hereditary spastic paraplegias (HSP s) are a heterogeneous group of disorders
characterized by spasticity in the lower limbs. We provide an overview of HSP with an …

The hereditary spastic paraplegias (HSPs) are among the most genetically diverse
neurological disorders, with almost 60 distinct genetic loci already mapped and over 30 …

Mouse models of human disorders provide critical tools in translational medicine to unravel
pathogenic mechanisms and develop therapeutic strategies. Hereditary spastic paraplegia …

Background Next‐generation sequencing‐based molecular assessment has benefited the
diagnosis of hereditary spastic paraplegia (HSP) subtypes. However, the clinical and …

Background Although the typical inheritance of spastic paraplegia 7 is recessive, several
reports have suggested that SPG7 variants may also cause autosomal dominant hereditary …

Background Spinal cord has been considered the main target of damage in hereditary
spastic paraplegias (HSPs), but mounting evidence indicates that the brain is also affected …

Background Familial hereditary spastic paraplegia (HSP)‐SPAST (SPG4) typically presents
with a pure HSP phenotype. Objective The aim of this study was to delineate the genotypic …

Background Hereditary spastic paraplegias (HSP) are neurologic disorders characterized by
progressive lower‐extremity spasticity. Despite the identification of several HSP‐related …

Abstract Background Hereditary Spastic Paraparesis (HSP) are a group of genetically
inherited disorders, clinically and genetically heterogenous and characterized by …

Objectives To diagnose the molecular cause of hereditary spastic paraplegia (HSP)
observed in a four‐generation family with autosomal dominant inheritance. Methods …