Dynamic metabolomics studies can provide a systematic view of the metabolic trajectory
during disease development and drug treatment and reveal the nature of biological …

Highlights Developed a data preprocessing strategy to cope with missing values and mask
effects in data analysis from high variation of abundant metabolites. A new method-'x …

Metabolomics is the sophisticated and high‐throughput technology based on the entire set
of metabolites which is known as the connector between genotypes and phenotypes. For …

Background: Metabolomics plays an important role in providing insight into the etiology and
mechanisms of hepatocellular carcinoma (HCC). This is accomplished by a comprehensive …

Background Hepatocellular carcinoma (HCC) is one of the deadliest cancers and is mainly
developed from chronic liver diseases such as hepatitis-B infection-associated liver cirrhosis …

Time-series metabolomics studies can provide insight into the dynamics of disease
development and facilitate the discovery of prospective biomarkers. To improve the …

BACKGROUND Early diagnosis of hepatocellular carcinoma may help to ensure that
patients have a chance for long-term survival; however, currently available biomarkers lack …

Hepatocellular carcinoma (HCC) is a common malignancy that has region specific
etiologies. Unfortunately, 85% of cases of HCC are diagnosed at an advanced stage …

Metabolomics has been shown to be an effective tool for biomarker screening and pathway
characterization and disease diagnosis. Metabolic characteristics of hepatocellular …

The aim of metabolomics is to identify, measure, and interpret complex time-related
concentration, activity, and flux of metabolites in cells, tissues, and biofluids. We have used a …