Evidence for the in vivo generation of oxidatively modified epitopes in patients with atherosclerotic endothelium

NA Le, X Li, S Kyung, WV Brown - Metabolism, 2000 - Elsevier
There is increasing evidence that autoantibodies (AAbs) against oxidatively modified low-
density lipoprotein (LDL) are present in humans and may be detected in fasting plasma …

Oxidized LDL and AGE-LDL in circulating immune complexes strongly predict progression of carotid artery IMT in type 1 diabetes

KJ Hunt, N Baker, P Cleary, JY Backlund, T Lyons… - Atherosclerosis, 2013 - Elsevier
Objective Over 90% of modified LDL in circulation is associated to specific antibodies
circulating as part of immune complexes (IC); however, few studies have examined their …

Low levels of apolipoprotein B-100 autoantibodies are associated with increased risk of coronary events

H Björkbacka, R Alm, M Persson… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Previous smaller studies have indicated inverse associations between
autoantibodies to oxidized low-density lipoprotein epitopes, and cardiovascular disease …

Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis

J George, A Afek, B Gilburd, H Levkovitz, A Shaish… - Atherosclerosis, 1998 - Elsevier
The role of the immune system in modulating atherosclerosis has recently been the subject
of intensive research. Several previous authors have put forward a paradigm of the …

Regulating protective immunity in atherosclerosis

J Nilsson - Circulation research, 2005 - Am Heart Assoc
Atherosclerosis is a disease characterized by chronic inflammation. Looking back it is almost
embarrassing how long it took for us to realize that the presence of these innate immune …

Autoimmunity, oxidized LDL and cardiovascular disease

J Frostegård - Autoimmunity reviews, 2002 - Elsevier
Atherosclerosis is the major cause of cardiovascular disease (CVD) and in addition to
established risk factors as smoking, hypertension, diabetes and dyslipidemia, inflammation …

Autoantibodies to oxidized LDL and cardiovascular risk: the Framingham Offspring Study

PWF Wilson, O Ben-Yehuda, J McNamara, J Massaro… - Atherosclerosis, 2006 - Elsevier
BACKGROUND: The relation between measures of oxidation of lipid particles and
cardiovascular disease has not been extensively investigated prospectively on a population …

Autoantibodies against modified low-density lipoproteins in coronary artery disease

P Tornvall, G Waeg, J Nilsson, A Hamsten… - Atherosclerosis, 2003 - Elsevier
Objectives: To evaluate the importance of different autoantibodies against modified low-
density lipoprotein (LDL) in patients with coronary artery disease (CAD). Background …

The role of innate and adaptive immunity to oxidized low‐density lipoprotein in the development of atherosclerosis

K Kobayashi, LR Lopez, Y Shoenfeld… - Annals of the New …, 2005 - Wiley Online Library
Atherosclerosis is a chronic inflammatory process of the arterial wall associated with
systemic and local immune responses to various antigens, oxidized low‐density lipoprotein …

Patients with early-onset peripheral vascular disease have increased levels of autoantibodies against oxidized LDL

C Bergmark, R Wu, U Faire, AK Lefvert… - … , and vascular biology, 1995 - Am Heart Assoc
Oxidative modification of LDL has been proposed as an early and crucial step in the
development of atherosclerosis, and antibodies against such modified LDL are found in both …