Diabetes is an independent risk factor in the development of atherosclerosis, although the
pathophysiological processes underlying this association are poorly understood. The …

Metabolic syndrome (MetS) is an inflammatory state associated with high coronary disease
risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability …

BACKGROUND: Electronegative low-density lipoprotein (LDL−) promotes atherosclerosis
through inflammatory and immunologic mechanisms that lead to the production of anti-LDL …

We and others previously showed that immunization of rabbits with different forms of
oxidized low density lipoprotein (LDL) significantly reduced atherogenesis. We now …

Accumulating evidence supports an autoimmune mechanism as one of the prime
pathogenic processes involved in the development of atherosclerosis. So far, three proteins …

Several groups have published results from clinical studies supporting the involvement of
anti-modified LDL antibodies as risk factors for the initiation or progression of cardiovascular …

Antibodies to oxidized LDL (ox-LDL) and LDL-containing immune complexes (LDL-IC) have
been reported to be associated with the presence or progression of arteriosclerosis. We …

Oxidatively modified LDLs are antigenic and elicit the generation of autoantibodies often
detected in plasma and within plaques of atherosclerotic patients. Although Cu2+-oxidized …

The role of oxidized low-density lipoprotein (ox-LDL) in the pathogenesis of atherosclerosis
has been the object of intense investigation. It has been proposed that, due to the antigenic …

Current strategies for prevention of cardiovascular disease focus on risk factor intervention.
Although these have been proven both safe and effective results from randomized clinical …