[HTML][HTML] Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma

X Liang, J Cui, X Yang, N Xia, Y Li, J Zhao… - Journal of Biological …, 2020 - ASBMB
Toxoplasma gondii is a common protozoan parasite that infects a wide range of hosts,
including livestock and humans. Previous studies have suggested that the type 2 fatty acid …

TgPL2, a patatin‐like phospholipase domain‐containing protein, is involved in the maintenance of apicoplast lipids homeostasis in Toxoplasma

MF Lévêque, L Berry, Y Yamaryo‐Botté… - Molecular …, 2017 - Wiley Online Library
Patatin‐like phospholipases are involved in numerous cellular functions, including lipid
metabolism and membranes remodeling. The patatin‐like catalytic domain, whose …

[HTML][HTML] Phosphatidylinositol 3-Monophosphate Is Involved in Toxoplasma Apicoplast Biogenesis

L Tawk, JF Dubremetz, P Montcourrier… - PLoS …, 2011 - journals.plos.org
Apicomplexan parasites cause devastating diseases including malaria and toxoplasmosis.
They harbour a plastid-like, non-photosynthetic organelle of algal origin, the apicoplast …

[HTML][HTML] Lipid analysis of Eimeria sporozoites reveals exclusive phospholipids, a phylogenetic mosaic of endogenous synthesis, and a host-independent lifestyle

P Kong, MJ Lehmann, JB Helms, JF Brouwers… - Cell Discovery, 2018 - nature.com
Successful inter-host transmission of most apicomplexan parasites requires the formation of
infective sporozoites within the oocysts. Unlike all other infective stages that are strictly …

[HTML][HTML] Host-lipidome as a potential target of protozoan parasites

A Rub, M Arish, SA Husain, N Ahmed, Y Akhter - Microbes and infection, 2013 - Elsevier
Host-lipidome caters parasite interaction by acting as first line of recognition, attachment on
the cell surface, intracellular trafficking, and survival of the parasite inside the host cell. Here …

[HTML][HTML] Characterization of acyl carrier protein and LytB in Babesia bovis apicoplast

MC Caballero, MJ Pedroni, GH Palmer… - Molecular and …, 2012 - Elsevier
The apicoplast is a highly specialized organelle that mediates required functions in the
growth and replication of apicomplexan parasites. Despite structural conservation of the …

[HTML][HTML] Plastid–endomembrane connections in apicomplexan parasites

MJ Boucher, E Yeh - PLoS Pathogens, 2019 - journals.plos.org
The apicoplast is a nonphotosynthetic plastid found in most apicomplexan parasites,
including Plasmodium spp.(causative agents of malaria) and Toxoplasma gondii (causative …

Disruption of apicoplast biogenesis by chemical stabilization of an imported protein evades the delayed-death phenotype in malaria parasites

MJ Boucher, E Yeh - MSphere, 2019 - Am Soc Microbiol
Malaria parasites (Plasmodium spp.) contain a nonphotosynthetic plastid organelle called
the apicoplast, which houses essential metabolic pathways and is required throughout the …

[HTML][HTML] Two apicoplast dwelling glycolytic enzymes provide key substrates for metabolic pathways in the apicoplast and are critical for Toxoplasma growth

Z Niu, S Ye, J Liu, M Lyu, L Xue, M Li, C Lyu… - PLoS …, 2022 - journals.plos.org
Many apicomplexan parasites harbor a non-photosynthetic plastid called the apicoplast,
which hosts important metabolic pathways like the methylerythritol 4-phosphate (MEP) …

New proteins in the apicoplast membranes: time to rethink apicoplast protein targeting

L Lim, M Kalanon, GI McFadden - Trends in parasitology, 2009 - cell.com
Several apicomplexan parasites harbour an essential plastid known as the apicoplast.
Apicoplasts import proteins and metabolites for several biological functions, but how import …