Modulation of NRF2: biological dualism in cancer, targets and possible therapeutic applications
M Gallorini, S Carradori, E Panieri, M Sova… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …
Inhibition of the NRF2/KEAP1 axis: a promising therapeutic strategy to alter redox balance of cancer cells
E Panieri, L Saso - Antioxidants & Redox Signaling, 2021 - liebertpub.com
Significance: The nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated
protein 1 (NRF2/KEAP1) pathway is a crucial and highly conserved defensive system that is …
protein 1 (NRF2/KEAP1) pathway is a crucial and highly conserved defensive system that is …
[HTML][HTML] Potential applications of NRF2 modulators in cancer therapy
The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …
Activators and inhibitors of NRF2: a review of their potential for clinical development
N Robledinos-Antón… - Oxidative medicine …, 2019 - Wiley Online Library
The transcription factor NRF2 (nuclear factor erythroid 2‐related factor 2) triggers the first
line of homeostatic responses against a plethora of environmental or endogenous …
line of homeostatic responses against a plethora of environmental or endogenous …
[HTML][HTML] Normal and pathological NRF2 signalling in the central nervous system
T Heurtaux, DS Bouvier, A Benani, S Helgueta Romero… - Antioxidants, 2022 - mdpi.com
The nuclear factor erythroid 2-related factor 2 (NRF2) was originally described as a master
regulator of antioxidant cellular response, but in the time since, numerous important …
regulator of antioxidant cellular response, but in the time since, numerous important …
Perspectives on the clinical development of NRF2-targeting drugs
D Lastra, R Fernández-Ginés, G Manda… - Reactive Oxygen …, 2021 - Springer
The transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) triggers
homeostatic responses against a plethora of environmental or endogenous deviations in …
homeostatic responses against a plethora of environmental or endogenous deviations in …
The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer
DD Zhang - Antioxidants & redox signaling, 2010 - liebertpub.com
The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at
low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight …
low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight …
[HTML][HTML] A pivotal role of Nrf2 in neurodegenerative disorders: A new way for therapeutic strategies
Clinical and preclinical research indicates that neurodegenerative diseases are
characterized by excess levels of oxidative stress (OS) biomarkers and by lower levels of …
characterized by excess levels of oxidative stress (OS) biomarkers and by lower levels of …
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated …
A Bresciani, A Missineo, M Gallo, M Cerretani… - Archives of biochemistry …, 2017 - Elsevier
Mechanisms that activate innate antioxidant responses, as a way to mitigate oxidative stress
at the site of action, hold much therapeutic potential in diseases, such as Parkinson's …
at the site of action, hold much therapeutic potential in diseases, such as Parkinson's …
[HTML][HTML] Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy
The Nuclear factor erythroid2-related factor2 (Nrf2), a master regulator of redox
homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant …
homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant …