Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery

S Lau, J Fei, H Liu, W Chen, R Liu - Journal of Controlled Release, 2017 - Elsevier
Dissolving microneedles have been employed as a safe and convenient transdermal
delivery system for drugs and vaccines. To improve effective drug delivery, a multilayered …

Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats

MH Ling, MC Chen - Acta biomaterialia, 2013 - Elsevier
This study presents a dissolving microneedle patch, composed of starch and gelatin, for the
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …

Fabrication of dissolving polymer microneedles for controlled drug encapsulation and delivery: bubble and pedestal microneedle designs

LY Chu, SO Choi, MR Prausnitz - Journal of pharmaceutical sciences, 2010 - Elsevier
Dissolving microneedle patches offer promise as a simple, minimally invasive method of
drug and vaccine delivery to the skin that avoids the need for hypodermic needles. However …

Study on the fabrication and characterization of tip-loaded dissolving microneedles for transdermal drug delivery

J Zhuang, F Rao, D Wu, Y Huang, H Xu, W Gao… - European Journal of …, 2020 - Elsevier
In order to increase the utilization rate of drug carried by microneedles and reduce waste, a
two-step casting method was proposed to fabricate tip-loaded dissolving microneedles in …

Dissolving microneedles for transdermal drug delivery

JW Lee, JH Park, MR Prausnitz - Biomaterials, 2008 - Elsevier
Microfabrication technology has been adapted to produce micron-scale needles as a safer
and painless alternative to hypodermic needle injection, especially for protein …

Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration

MG McGrath, S Vucen, A Vrdoljak, A Kelly… - European Journal of …, 2014 - Elsevier
Dissolvable microneedles offer an attractive delivery system for transdermal drug and
vaccine delivery. They are most commonly formed by filling a microneedle mold with liquid …

[HTML][HTML] Dissolving microneedles: Applications and growing therapeutic potential

Z Sartawi, C Blackshields, W Faisal - Journal of Controlled Release, 2022 - Elsevier
Microneedles are a rapidly developing method for the transdermal delivery of therapeutic
compounds. All types of microneedles, whether solid, hollow, coated, or dissolving function …

Formulation of two‐layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice

IC Lee, WM Lin, JC Shu, SW Tsai… - … research Part A, 2017 - Wiley Online Library
Dissolving microneedles (MNs) display high efficiency in delivering poorly permeable drugs
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …

Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine

X Hong, L Wei, F Wu, Z Wu, L Chen, Z Liu… - Drug design …, 2013 - Taylor & Francis
Microneedles were first conceptualized for drug delivery many decades ago, overcoming the
shortages and preserving the advantages of hypodermic needle and conventional …

Dissolving microneedle patches for transdermal insulin delivery in diabetic mice: potential for clinical applications

CH Chen, VBH Shyu, CT Chen - Materials, 2018 - mdpi.com
In this study, dissolving polymeric microneedle (MN) patches composed of gelatin and
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …