Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery
S Lau, J Fei, H Liu, W Chen, R Liu - Journal of Controlled Release, 2017 - Elsevier
Dissolving microneedles have been employed as a safe and convenient transdermal
delivery system for drugs and vaccines. To improve effective drug delivery, a multilayered …
delivery system for drugs and vaccines. To improve effective drug delivery, a multilayered …
Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats
MH Ling, MC Chen - Acta biomaterialia, 2013 - Elsevier
This study presents a dissolving microneedle patch, composed of starch and gelatin, for the
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …
Fabrication of dissolving polymer microneedles for controlled drug encapsulation and delivery: bubble and pedestal microneedle designs
LY Chu, SO Choi, MR Prausnitz - Journal of pharmaceutical sciences, 2010 - Elsevier
Dissolving microneedle patches offer promise as a simple, minimally invasive method of
drug and vaccine delivery to the skin that avoids the need for hypodermic needles. However …
drug and vaccine delivery to the skin that avoids the need for hypodermic needles. However …
Study on the fabrication and characterization of tip-loaded dissolving microneedles for transdermal drug delivery
J Zhuang, F Rao, D Wu, Y Huang, H Xu, W Gao… - European Journal of …, 2020 - Elsevier
In order to increase the utilization rate of drug carried by microneedles and reduce waste, a
two-step casting method was proposed to fabricate tip-loaded dissolving microneedles in …
two-step casting method was proposed to fabricate tip-loaded dissolving microneedles in …
Dissolving microneedles for transdermal drug delivery
JW Lee, JH Park, MR Prausnitz - Biomaterials, 2008 - Elsevier
Microfabrication technology has been adapted to produce micron-scale needles as a safer
and painless alternative to hypodermic needle injection, especially for protein …
and painless alternative to hypodermic needle injection, especially for protein …
Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration
MG McGrath, S Vucen, A Vrdoljak, A Kelly… - European Journal of …, 2014 - Elsevier
Dissolvable microneedles offer an attractive delivery system for transdermal drug and
vaccine delivery. They are most commonly formed by filling a microneedle mold with liquid …
vaccine delivery. They are most commonly formed by filling a microneedle mold with liquid …
[HTML][HTML] Dissolving microneedles: Applications and growing therapeutic potential
Microneedles are a rapidly developing method for the transdermal delivery of therapeutic
compounds. All types of microneedles, whether solid, hollow, coated, or dissolving function …
compounds. All types of microneedles, whether solid, hollow, coated, or dissolving function …
Formulation of two‐layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice
Dissolving microneedles (MNs) display high efficiency in delivering poorly permeable drugs
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …
Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
X Hong, L Wei, F Wu, Z Wu, L Chen, Z Liu… - Drug design …, 2013 - Taylor & Francis
Microneedles were first conceptualized for drug delivery many decades ago, overcoming the
shortages and preserving the advantages of hypodermic needle and conventional …
shortages and preserving the advantages of hypodermic needle and conventional …
Dissolving microneedle patches for transdermal insulin delivery in diabetic mice: potential for clinical applications
CH Chen, VBH Shyu, CT Chen - Materials, 2018 - mdpi.com
In this study, dissolving polymeric microneedle (MN) patches composed of gelatin and
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …
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