[HTML][HTML] Systemic delivery to central nervous system by engineered PLGA nanoparticles
Q Cai, L Wang, G Deng, J Liu, Q Chen… - American journal of …, 2016 - ncbi.nlm.nih.gov
Neurological disorders are an important global public health problem, but pharmaceutical
treatments are limited due to drug access to the central nervous system being restricted by …
treatments are limited due to drug access to the central nervous system being restricted by …
PLA/PLGA nanoparticles for delivery of drugs across the blood-brain barrier
J Li, C Sabliov - Nanotechnology Reviews, 2013 - degruyter.com
The blood-brain barrier (BBB), which protects the central nervous system (CNS) from
unnecessary substances, is a challenging obstacle in the treatment of CNS disease. Many …
unnecessary substances, is a challenging obstacle in the treatment of CNS disease. Many …
PLGA nanoparticle-based formulations to cross the blood–brain barrier for drug delivery: From R&D to cGMP
The blood–brain barrier (BBB) is a natural obstacle for drug delivery into the human brain,
hindering treatment of central nervous system (CNS) disorders such as acute ischemic …
hindering treatment of central nervous system (CNS) disorders such as acute ischemic …
PLGA-based nanoparticles for neuroprotective drug delivery in neurodegenerative diseases
A Cunha, A Gaubert, L Latxague, B Dehay - Pharmaceutics, 2021 - mdpi.com
Treatment of neurodegenerative diseases has become one of the most challenging topics of
the last decades due to their prevalence and increasing societal cost. The crucial point of the …
the last decades due to their prevalence and increasing societal cost. The crucial point of the …
Multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics
S Shakeri, M Ashrafizadeh, A Zarrabi, R Roghanian… - Biomedicines, 2020 - mdpi.com
The blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS)
from damage by substances that originate from the blood circulation. The BBB limits drug …
from damage by substances that originate from the blood circulation. The BBB limits drug …
PLGA-based nanoparticles: an overview of biomedical applications
Poly (lactic-co-glycolic acid)(PLGA) is one of the most successfully developed
biodegradable polymers. Among the different polymers developed to formulate polymeric …
biodegradable polymers. Among the different polymers developed to formulate polymeric …
Potential use of polymeric nanoparticles for drug delivery across the blood-brain barrier
G Tosi, B Bortot, B Ruozi, D Dolcetta… - Current medicinal …, 2013 - ingentaconnect.com
Nanomedicine is certainly one of the scientific and technological challenges of the coming
years. In particular, biodegradable nanoparticles formulated from poly (D, L-lactide-co …
years. In particular, biodegradable nanoparticles formulated from poly (D, L-lactide-co …
Functionalized PLGA nanoparticles prepared by nano-emulsion templating interact selectively with proteins involved in the transport through the blood-brain barrier
M Monge, C Fornaguera, C Quero, A Dols-Perez… - European Journal of …, 2020 - Elsevier
During the last few decades, extensive efforts has been made to design nanocarriers to
transport drugs into the central nervous system (CNS). However, its efficacy is limited due to …
transport drugs into the central nervous system (CNS). However, its efficacy is limited due to …
Brain targeting with surface-modified poly (D, L-lactic-co-glycolic acid) nanoparticles delivered via carotid artery administration
K Tahara, Y Miyazaki, Y Kawashima, J Kreuter… - European Journal of …, 2011 - Elsevier
In this study, we investigated surface-modified nanoparticles (NP) formulated using a
biodegradable polymer, poly (d, l-lactide-co-glycolide)(PLGA), for targeting central nervous …
biodegradable polymer, poly (d, l-lactide-co-glycolide)(PLGA), for targeting central nervous …
The recent applications of plga-based nanostructures for ischemic stroke
J Yan, L Huang, J Feng, X Yang - Pharmaceutics, 2023 - mdpi.com
With the accelerated development of nanotechnology in recent years, nanomaterials have
become increasingly prevalent in the medical field. The poly (lactic acid–glycolic acid) …
become increasingly prevalent in the medical field. The poly (lactic acid–glycolic acid) …