Activation of the Nrf2 signaling pathway involving KLF9 plays a critical role in allicin resisting against arsenic trioxide-induced hepatotoxicity in rats
D Yang, Z Lv, H Zhang, B Liu, H Jiang, X Tan… - Biological trace element …, 2017 - Springer
Abstract Arsenic trioxide (As 2 O 3) is both the most prevalent, naturally occurring inorganic
arsenical threatening human health and an efficient therapeutic for acute promyelocytic …
arsenical threatening human health and an efficient therapeutic for acute promyelocytic …
[HTML][HTML] Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2
G Xie, X Meng, F Wang, Y Bao, J Huo - Oncotarget, 2017 - ncbi.nlm.nih.gov
Arsenic, a well-known human carcinogen, has been reported to induce hepatic oxidative
stress and hepatic injury. Eriodictyol, a flavonoid found in citrus fruits, has been reported to …
stress and hepatic injury. Eriodictyol, a flavonoid found in citrus fruits, has been reported to …
Allicin mitigates hepatic injury following cyclophosphamide administration via activation of Nrf2/ARE pathways and through inhibition of inflammatory and apoptotic …
D Sun, C Sun, G Qiu, L Yao, J Yu, H Al Sberi… - … Science and Pollution …, 2021 - Springer
Abstract Treatment with anti-neoplastic agents, including cyclophosphamide (CP), is
associated with several adverse reactions. Here, we distinguished the potential protective …
associated with several adverse reactions. Here, we distinguished the potential protective …
Nrf2 protects against As (III)-induced damage in mouse liver and bladder
Arsenic compounds are classified as toxicants and human carcinogens. Environmental
exposure to arsenic imposes a big health issue worldwide. Arsenic elicits its toxic efforts …
exposure to arsenic imposes a big health issue worldwide. Arsenic elicits its toxic efforts …
Allicin alleviated acrylamide-induced NLRP3 inflammasome activation via oxidative stress and endoplasmic reticulum stress in Kupffer cells and SD rats liver
B Nan, C Yang, L Li, H Ye, H Yan, M Wang… - Food and Chemical …, 2021 - Elsevier
Acrylamide (AA) in heat-processed food leads to widespread concerns due to its
hepatotoxicity. Allicin, a plant-derived antioxidant, possesses a significant protective effect …
hepatotoxicity. Allicin, a plant-derived antioxidant, possesses a significant protective effect …
Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway
Aflatoxin B1 (AFB1), a threatening mycotoxin, usually provokes oxidative stress and causes
hepatotoxicity in animals and humans. Luteolin (LUTN), well-known as an active …
hepatotoxicity in animals and humans. Luteolin (LUTN), well-known as an active …
Hepatoprotective effect of allicin against acetaminophen‐induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration
Acetaminophen (APAP) overdose leads to liver injury. NLRP3 inflammasome is a key player
in APAP‐induced inflammation. Also, apoptosis and liver regeneration play an important …
in APAP‐induced inflammation. Also, apoptosis and liver regeneration play an important …
Lycopene relieves AFB1-induced liver injury through enhancing hepatic antioxidation and detoxification potential with Nrf2 activation
F Xu, K Yu, H Yu, P Wang, M Song, C Xiu, Y Li - Journal of functional foods, 2017 - Elsevier
To evaluate the chemoprotective effect and mechanism of lycopene (LYC) on aflatoxin B 1
(AFB 1)-induced liver injury, forty-eight male mice were randomly allocated and treated with …
(AFB 1)-induced liver injury, forty-eight male mice were randomly allocated and treated with …
[HTML][HTML] Rosmarinic acid alleviates acetaminophen-induced hepatotoxicity by targeting Nrf2 and NEK7-NLRP3 signaling pathway
Y Yao, R Li, D Liu, L Long, N He - Ecotoxicology and Environmental Safety, 2022 - Elsevier
Rosmarinic acid (RA) is a natural polyphenol with various biological activities, such as anti-
oxidative, anti-fibrotic, and hepatoprotective properties. The objective of this study was to …
oxidative, anti-fibrotic, and hepatoprotective properties. The objective of this study was to …
Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway
H Lv, L Hong, Y Tian, C Yin, C Zhu, H Feng - Cell communication and …, 2019 - Springer
Background Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly
resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) …
resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) …