Introduction: Mortality due to severe infections in critically ill patients undergoing continuous
renal replacement therapy (CRRT) remains high. Nevertheless, rapid administration of …

Emerging studies indicate that, in addition to drug accumulation, subtherapeutic antibiotic
concentrations may affect the outcome of therapy during renal replacement therapy (RRT) in …

Objectives: In critically ill patients receiving continuous renal replacement therapy, we aimed
to assess the variability of antibiotic trough concentrations, the influence of effluent flow rates …

Determining appropriate antibiotic dosing for critically ill patients receiving renal
replacement therapy (RRT) is complex. Worldwide unstandardized and heterogeneous …

Acute kidney injury (AKI) is a common complication in critically ill patients, which is
associated with increased in‐hospital mortality. Delivering effective antibiotics to treat …

Critically ill patients with sepsis admitted to the intensive care unit (ICU) often present with or
develop renal dysfunction requiring renal replacement therapy (RRT) in addition to …

Background The optimal dosing of antibiotics in critically ill patients receiving renal
replacement therapy (RRT) remains unclear. In this study, we describe the variability in RRT …

Critically ill patients are frequently affected by acute kidney injury accompanied by
dysfunction of other systems and organs. Sepsis is common in this population and remains a …

Background Drug dosing for septic patients with acute renal failure receiving continuous
renal replacement therapy (CRRT) is complicated, and failure to correctly dose may result in …

Acute kidney injury represents a common complication in critically ill patients affected by
septic shock and in many cases continuous renal replacement therapy (CRRT) may be …