Chronic pain is an important public health problem that negatively impacts the quality of life
of affected individuals and exacts enormous socioeconomic costs. Chronic pain is often …

Brain processing of pain in humans is based on multiple ascending pathways and brain
regions that are involved in several pain components, such as sensory, immediate affective …

The perception of pain is sensitive to various mental processes such as the feelings and
beliefs that someone has about pain. It is therefore not exclusively driven by the noxious …

Pain is a highly complex and subjective experience that is not linearly related to the
nociceptive input. What is clear from anecdotal reports over the centuries and more recently …

All pain is unpleasant, but different perceptual and emotional qualities are characteristic of
pain originating in different structures. Pain of superficial (cutaneous) origin usually is sharp …

Neural circuits that determine the perception and modulation of pain remain poorly
understood. The prefrontal cortex (PFC) provides top-down control of sensory and affective …

Functional imaging studies of human subjects have identified a diverse assortment of brain
areas that are engaged in the processing of pain. Although many of these brain areas are …

Pain: Integration of Sensory and Affective Aspects of Pain: Current Biology Skip to Main
Content Advertisement Current Biology This journal offers authors two options (open access or …

Pain is a uniquely individual experience that is heavily shaped by evaluation and judgments
about afferent sensory information. In visual, auditory, and tactile sensory modalities …

The central amygdala (CE) emerges as a critical node for affective processing. However,
how CE local circuitry interacts with brain wide affective states is yet uncharted. Using basic …