Along with a general decline in overall health, most chronic degenerative human diseases
are inherently associated with increasing age. Age-associated cognitive impairments and …

Increased life expectancies have significantly increased the number of individuals suffering
from geriatric neurodegenerative diseases such as Alzheimer's disease (AD) and …

Cellular senescence is a state of terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells …

The term cellular senescence was introduced more than five decades ago to describe the
state of growth arrest observed in aging cells. Since this initial discovery, the phenotypes …

In 1960, Rita Levi-Montalcini and Barbara Booker made an observation that transformed
neuroscience: as neurons mature, they become apoptosis resistant. The following year …

Life expectancy has increased substantially over the last few decades, leading to a
worldwide increase in the prevalence and burden of aging-associated diseases. Recent …

Cellular senescence is a potent anti-cancer mechanism that arrests the proliferation of
mitotically competent cells to prevent malignant transformation. Senescent cells accumulate …

Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …