Nanoparticulate drug delivery systems for cancer chemotherapy

RN Saha, S Vasanthakumar, G Bende… - Molecular membrane …, 2010 - Taylor & Francis
Nanoparticles (NPs) are, in general, colloidal particles, less than 1000 nm, that can be used
for better drug delivery and prepared either by encapsulating the drug within a vesicle and …

Introduction for design of nanoparticle based drug delivery systems

J Yan Chan Edgar, H Wang - Current Pharmaceutical Design, 2017 - ingentaconnect.com
Conventional drug delivery systems contain numerous limitations such as limited targeting,
low therapeutic indices, poor water solubility, and the induction of drug resistances. In order …

Deep penetration of nanoparticulate drug delivery systems into tumors: challenges and solutions

L Li, J Sun, Z He - Current medicinal chemistry, 2013 - ingentaconnect.com
In recent decades, nanoparticulate drug delivery systems have attracted extensive attention
in cancer therapy for such appealing properties as small particle size, huge surface area …

Advanced engineered nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites

J Cao, D Huang, NA Peppas - Advanced drug delivery reviews, 2020 - Elsevier
The widespread development of nanocarriers to deliver chemotherapeutics to specific tumor
sites has been motivated by the lack of selective targeting during chemotherapy inducing …

Functionalization of nanoparticulate drug delivery systems and its influence in cancer therapy

TA Seidu, PT Kutoka, DO Asante, MA Farooq… - Pharmaceutics, 2022 - mdpi.com
Research into the application of nanocarriers in the delivery of cancer-fighting drugs has
been a promising research area for decades. On the other hand, their cytotoxic effects on …

Nanocarriers: promising vehicle for bioactive drugs

M Rawat, D Singh, S Saraf, S Saraf - Biological and Pharmaceutical …, 2006 - jstage.jst.go.jp
Development of new delivery systems that deliver the potential drug specifically to the target
site in order to meet the therapeutic needs of the patients at the required time and level …

Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

VP Torchilin - Nature reviews Drug discovery, 2014 - nature.com
The use of nanoparticulate pharmaceutical drug delivery systems (NDDSs) to enhance the
in vivo effectiveness of drugs is now well established. The development of multifunctional …

Nanoparticulate systems for brain delivery of drugs

J Kreuter - Advanced drug delivery reviews, 2001 - Elsevier
The blood–brain barrier (BBB) represents an insurmountable obstacle for a large number of
drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system …

Pharmacokinetic behaviors of soft nanoparticulate formulations of chemotherapeutics

M Sarkar, Y Wang, O Ekpenyong… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Chemotherapeutic treatment with conventional drug formulations pose numerous
challenges, such as poor solubility, high cytotoxicity and serious off‐target side effects, low …

Nanotechnology in drug development and life cycle management

S Majuru, MO Oyewumi - Nanotechnology in drug delivery, 2009 - Springer
Nanotechnology deals with the design, production, characterization and application of sub-
micron-sized particles. The popularity and effectiveness of small-sized particles can be …