Amyotrophic lateral sclerosis (ALS), although a disease that has been well recognized for
nearly 150 years, still causes problems of diagnosis and management, as there is no …

The classification and nomenclature of motor neuron disease, whether sporadic or familial,
is confused. For example, both the sporadic and familial motor neuron diseases are …

Motor neuron disease, from diagnostic criteria, laboratory evaluation, communication with
patients and their families, and the approach to long-term management represents a …

Diseases affecting motor neurons, such as amyotrophic lateral sclerosis (Lou Gerhig's
disease), hereditary spastic paraplegia and spinal bulbar muscular atrophy (Kennedy's …

Amyotrophic lateral sclerosis (ALS), first described by Charcot in the 19 th century, is a
relentlessly progressive, presently incurable neurodegenerative disorder that causes …

Amyotrophic lateral sclerosis or motor neurone disease is one of the most debilitating and
devastating of the neurological diseases. The only comprehensive textbook available on the …

Most patients with amyotrophic lateral sclerosis (ALS) have the sporadic form of this disease.
In 5 to 10% of cases, ALS is a familial disorder, usually being transmitted as an autosomal …

Publisher Summary This chapter discusses the epidemiology, clinical phenotype, and
genetic basis of the heritable forms of motor neuron disorder (MND) that have been …

Amyotrophic Lateral Sclerosis/Motor Neuron Disease is a relentlessly progressive
neurodegenerative disorder. It is characterised by progressive loss of neurons resulting in …

OBJECTIVE To understand the mechanisms causing neuronal death in amyotrophic lateral
sclerosis (ALS), an electrophysiological technique of motor unit number estimation (MUNE) …