Multidrug-resistant tuberculosis and beyond: an updated analysis of the current evidence on bedaquiline

E Pontali, L D'Ambrosio, R Centis… - European …, 2017 - Eur Respiratory Soc
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) continue
to be challenging at both the patient and programme level. The World Health Organization …

Bedaquiline-based treatment regimen for multidrug-resistant tuberculosis

ID Olaru, J Heyckendorf, S Andres… - European …, 2017 - Eur Respiratory Soc
Treatment outcomes for multidrug-resistant (MDR) tuberculosis (TB) are poor with only
approximately 50% of patients attaining treatment success [1]. An important driver of …

Should we worry about bedaquiline exposure in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis?

JWC Alffenaar, OW Akkerman, S Tiberi… - European …, 2020 - Eur Respiratory Soc
Recently, the World Health Organization (WHO) released the updated guideline on the
treatment for multi-drug resistant tuberculosis (MDR-TB) treatment regimens based on new …

Bedaquiline and multidrug-resistant tuberculosis: a systematic and critical analysis of the evidence

E Pontali, G Sotgiu, L D'Ambrosio… - European …, 2016 - Eur Respiratory Soc
The importance of adequately managing multidrug-resistant (MDR) and extensively drug-
resistant (XDR) tuberculosis (TB) cases for TB control and elimination are underlined in the …

Impact of bedaquiline on treatment outcomes of multidrug-resistant tuberculosis in a high-burden country

D Chesov, J Heyckendorf, S Alexandru… - European …, 2021 - Eur Respiratory Soc
Background Evaluation of novel anti-tuberculosis (TB) drugs for the treatment of multidrug-
resistant (MDR)-TB continues to be of high interest on the TB research agenda. We …

[PDF][PDF] Report of the guideline development group meeting on the use of bedaquiline in the treatment of multidrug-resistant tuberculosis: a review of available evidence …

World Health Organization - 2017 - apps.who.int
The issuance of the WHO interim policy guidance for the use of bedaquiline represented a
major milestone in the treatment and care of multidrug-resistant tuberculosis (MDR-TB) 1 …

Long-term outcome and safety of prolonged bedaquiline treatment for multidrug-resistant tuberculosis

L Guglielmetti, M Jaspard, D Le Dû… - European …, 2017 - Eur Respiratory Soc
Bedaquiline, a recently approved drug for the treatment of multidrug-resistant tuberculosis
(MDR-TB), is recommended for a duration of 24 weeks. There are scarce data on patients …

[HTML][HTML] Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort

S Koirala, S Borisov, E Danila, A Mariandyshev… - Pulmonology, 2021 - Elsevier
Abstract The World Health Organization (WHO) recommends countries introduce new anti-
TB drugs in the treatment of multidrug-resistant tuberculosis. The aim of the study is to …

Combined treatment of drug-resistant tuberculosis with bedaquiline and delamanid: a systematic review

E Pontali, G Sotgiu, S Tiberi, M Tadolini… - European …, 2018 - Eur Respiratory Soc
The World Health Organization (WHO) estimated that 490 000 cases of multidrug-resistant
(MDR) tuberculosis (TB)(defined as TB caused by Mycobacterium tuberculosis strains …

Bedaquiline safety, efficacy, utilization and emergence of resistance following treatment of multidrug-resistant tuberculosis patients in South Africa: a retrospective …

H Pai, N Ndjeka, L Mbuagbaw, K Kaniga… - BMC infectious …, 2022 - Springer
Background This retrospective cohort study assessed benefits and risks of bedaquiline
treatment in multidrug-resistant-tuberculosis (MDR-TB) combination therapy by evaluating …