Among the most important targets for chemopreventive intervention and drug development
are deregulated signal transduction pathways, and protein tyrosine kinases are key …

The epidermal growth factor receptor (EGFR) is overexpressed and/or constitutively
activated in a variety of human malignancies. Detection of increased expression levels of …

Clinical trials of selective small-molecule inhibitors of epidermal growth factor receptor
tyrosine kinase activity have shown that these targeted inhibitors of proliferative signal …

Progress in identifying and understanding the molecular and cellular causes of cancer has
led to the discovery of anomalies that characterize cancer cells and that represent targets for …

Much effort has been expended in the search for inhibitors of signalling molecules that may
prove to be important therapeutically in cancer. The epidermal growth factor receptor …

Functional activation of growth factors and receptors of the epidermal growth factor receptor
(EGFR) family occurs in most epithelial-cell cancers, rendering EGFR a target for cancer …

In cancer cells, aberrant signaling through the epidermal growth factor receptor (EGFR)
activates pathways that stimulate many of the properties associated with neoplasia …

From immunohistochemical and ligand-binding studies, it is known that the epidermal
growth factor receptor (EGFR), a member of the erbB family of receptors, is expressed in …

The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family
that is abnormally activated in many epithelial tumors. Receptor activation leads to …

Background: Growth factor receptor-signaling pathways are potentially important targets for
anticancer therapy. The interaction of anticancer agents with specific molecular targets can …