Xanthine oxidoreductase (XOR) is the enzyme responsible for the final step in purine
degradation resulting in the generation of uric acid. Here we have generated mice deficient …

Cardiovascular diseases (CVD) are the leading cause of global mortality and their
pathogenesis lies mainly in the atherosclerotic process. There are close connections linking …

Background: Formerly, hyperuricemia was mainly restricted to the rich population, but now-a-
days it is a condition affecting wide parts of western civilization. Although only a minority of …

Endothelial xanthine oxidoreductase (XOR) together with NAD (P) H oxidase and nitric
oxide (NO) synthase plays a physiologic role in inflammatory signalling, the regulation of NO …

Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome
through the oxidative stress and the inflammatory response induced by XOR-derived …

Hyperuricemia is thought to play a role in cardiovascular diseases (CVD), including
hypertension, coronary artery disease and atherosclerosis. However, exactly how uric acid …

Hyperuricemia, defined as a serum uric acid (UA) level> 7.0 mg/dL in Japan [1], may be a
risk factor for the development of cerebrocardiovascular disease, and various intervention …

Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation
in purine metabolism, is involved in reactive oxygen species generation. Plasma XOR …

Background: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of
uric acid from hypoxanthine and xanthine, leading to an increase in superoxide and reactive …

Xanthine oxidoreductase (XOR) activity has been previously noted to be responsive to
changes in O2 tension. While prior studies have focused on the extremes (0–3% and 95 …