In addition to its critical role in purine metabolism, xanthine oxidoreductase (XOR) has been
implicated in the development of tissue oxidative damage in a wide variety of respiratory and …

Aims Xanthine oxidoreductase (XOR) is an enzyme regulating uric acid synthesis and
generation of reactive oxygen species. Several studies suggested relationship between …

Increased reactive oxygen species (ROS) contributes to the development of endothelial
dysfunction, which is involved in coronary artery spasm (CAS). Xanthine oxidoreductase …

Xanthine oxidase (XO) is an enzyme responsible for the production of uric acid. XO
produces considerable amount of oxidative stress throughout the body. To date, however, its …

Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors
for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological …

High uric acid levels are associated with increased morbidity and mortality rates in
cardiovascular disease. In this article we explore the relationship between cardiovascular …

Many studies have shown a strong correlation between urate levels and cardiovascular
disease. The formation of urate is complex as the same enzyme that produces urate …

Objective—Xanthine oxidoreductase (XOR) catalyzes the production of uric acid with
concomitant generation of reactive oxygen species. XOR has been shown to regulate …

Several experimental and clinical studies reported that hyperuricemia may trigger
hypertension, metabolic syndrome, vascular damage and renal disease. Furthermore, a …

Oxidative stress plays an important role in vascular complications observed in patients with
obesity and Type 2 Diabetes (T2D). Xanthine oxidase (XO) breaks down purine nucleotides …