Background We developed a novel high-sensitive assay for plasma xanthine
oxidoreductase (XOR) activity that is not affected by the original serum uric acid level …

The cytochrome P450 (CYP) enzymes participate in a wide range of biochemical functions,
including metabolism of arachidonic acid and steroid hormones. Mouse CYP2J5 is …

The enzyme xanthine oxidoreductase (XOR) catalyzes the last two steps of purine
catabolism in the highest uricotelic primates. XOR is an enzyme with dehydrogenase activity …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of arthritis
and pain. However, their long-term use is limited by gastrointestinal (GI) side effects such as …

Hyperuricemia (HU) is a cause of gout. Clinical studies show a link between HU and
cardiovascular disease. However, the role of soluble serum urate (SU) on atherosclerosis …

Atherosclerosis is a chronic inflammatory disease due to lipid deposition in the arterial wall.
Multiple mechanisms participate in the inflammatory process, including oxidative stress …

Hypertension may be associated with an increase in oxidative stress as a possible
mechanism for the increased vascular tone and organ injury. Previously, we reported an …

Background—Cigarette smoking causes endothelial dysfunction, possibly through
increased oxidant stress. The enzyme xanthine oxidase produces oxidative free radicals …

Evidence is increasing in hypertensive models for an inflammatory reaction in the
microcirculation with abnormal leukocyte counts and adhesion to the endothelium …

Borghi and Desideri Allopurinol and Cardiovascular Disease 497 the increase in the
endothelium-dependent forearm vasodilatation was enhanced by allopurinol in a dose …