Correction of pulmonary abnormalities in Sftpd-/-mice requires the collagenous domain of surfactant protein D

PS Kingma, L Zhang, M Ikegami, K Hartshorn… - Journal of Biological …, 2006 - ASBMB
Surfactant protein D (SP-D) is a member of the collectin family of innate defense proteins.
Members of this family share four distinct structural domains: an N-terminal cross-linking …

Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis

L Zhang, M Ikegami, TR Korfhagen… - … of Physiology-Lung …, 2006 - journals.physiology.org
Surfactant proteins (SP)-A and-D are members of the collectin family of host defense
proteins that share four distinct structural domains: NH2-terminal oligomerization …

Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo

TR Korfhagen, V Sheftelyevich, MS Burhans… - Journal of Biological …, 1998 - ASBMB
Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin
domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene …

Complementation of pulmonary abnormalities in SP-D (−/−) mice with an SP-D/conglutinin fusion protein

L Zhang, KL Hartshorn, EC Crouch, M Ikegami… - Journal of Biological …, 2002 - ASBMB
Surfactant protein D (SP-D) and serum conglutinin are closely related members of the
collectin family of host defense lectins. Although normally synthesized at different anatomic …

SP-D-deficient mice are resistant to hyperoxia

D Jain, E Atochina-Vasserman… - … of Physiology-Lung …, 2007 - journals.physiology.org
Surfactant protein D (SP-D), a member of the collectin superfamily, modulates pulmonary
inflammatory responses and innate immunity. Disruption of the SP-D gene in mice induces …

Alveolar macrophages and emphysema in surfactant protein‐d‐deficient mice

M Yoshida, JA Whitsett - Respirology, 2006 - Wiley Online Library
Surfactant protein‐D (SP‐D) is a member of the collectin family of collagenous proteins with
lectin activity. SP‐D is expressed in numerous tissues, primarily in type II alveolar cells in the …

Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors

M Yamazoe, C Nishitani, M Takahashi, T Katoh… - Journal of biological …, 2008 - ASBMB
Pulmonary surfactant protein D (SP-D) is a member of the collectin family that plays an
important role in regulating innate immunity of the lung. We examined the mechanisms by …

Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type II cells

M Ikegami, CL Na, TR Korfhagen… - American Journal of …, 2005 - journals.physiology.org
Surfactant protein D (SP-D) is a member of the collectin family of the innate host defense
proteins. In the lung, SP-D is expressed primarily by type II cells. Gene-targeted SP-D …

Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain

X Nie, C Nishitani, M Yamazoe, S Ariki… - Biochemistry, 2008 - ACS Publications
Pulmonary surfactant protein D (SP-D) is a member of the collectin family and plays crucial
roles in the innate immunity of the lung. We have previously shown that surfactant protein A …

Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D

C Botas, F Poulain, J Akiyama… - Proceedings of the …, 1998 - National Acad Sciences
Surfactant protein D (SP-D) is one of two collectins found in the pulmonary alveolus. On the
basis of homology with other collectins, potential functions for SP-D include roles in innate …