The strength of interactions between T cell receptors and the peptide-major
histocompatibility complex (pMHC) directly modulates T cell fitness, clonal expansion, and …

Asymmetric cell division is a potential means by which cell fate choices during an immune
response are orchestrated. Defining the molecular mechanisms that underlie asymmetric …

During adaptive immune responses, CD8+ T cells with low TCR affinities are released early
into the circulation before high-affinity clones become dominant at later time points. How …

T cells are critical in orchestrating protective immune responses to cancer and an array of
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …

Polarization of effector CD4+ T cells can be influenced by both antigen-specific signals and
by pathogen-or adjuvant-induced cytokines, with current models attributing a dominant role …

T cell homeostasis commonly refers to the maintenance of relatively stable T cell numbers in
the peripheral lymphoid organs. Among the large numbers of T cells in the periphery, T cells …

The development of a self-tolerant and effective T cell receptor repertoire is dependent on
interactions coordinated by various antigen presenting cells (APC) within the thymus. T cell …

T lymphocyte recognition of infected cells is mediated by T cell receptors (TCRs) interacting
with their ligands, self–major histocompatibility complex (MHC) molecules complexed with …

TCR-self peptide: MHC interactions play a critical role in thymic positive selection, yet
relatively little is known of their function in the periphery. It has been suggested that …

Activation of T helper cells is necessary for the adaptive immune response to pathogens,
and spurious activation can result in organ-specific autoimmunity (eg, multiple sclerosis). T …