Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease

JL Hoffman, S Faccidomo, M Kim, SM Taylor… - International review of …, 2019 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the
most common cause of dementia in the United States. Although the link between alcohol …

Alcohol as a modifiable risk factor for alzheimer's disease—evidence from experimental studies

DV Chandrashekar, RA Steinberg, D Han… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive impairment and memory loss. Epidemiological evidence suggests that heavy …

[HTML][HTML] Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice

SM Day, SC Gironda, CW Clarke, JA Snipes… - Neurobiology of …, 2023 - Elsevier
Epidemiological studies identified alcohol use disorder (AUD) as a risk factor for Alzheimer's
disease (AD), yet there is conflicting evidence on how alcohol use promotes AD pathology …

Adolescent binge alcohol enhances early Alzheimer's disease pathology in adulthood through proinflammatory neuroimmune activation

A Barnett, E David, A Rohlman, VD Nikolova… - Frontiers in …, 2022 - frontiersin.org
Epidemiological studies suggest that heavy alcohol use early in life is associated with
increased risk for Alzheimer's disease (AD). However, mechanisms connecting AD with …

Alcohol and Alzheimer's disease—does alcohol dependence contribute to beta-amyloid deposition, neuroinflammation and neurodegeneration in Alzheimer's disease …

A Venkataraman, N Kalk, G Sewell… - Alcohol and …, 2017 - academic.oup.com
Aims To investigate the underlying neurobiology between alcohol use, misuse and
dependence and cognitive impairment, particularly Alzheimer's disease (AD). Methods …

Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction

PT Nunes, BT Kipp, NL Reitz, LM Savage - International review of …, 2019 - Elsevier
Alcoholism is associated with brain damage and impaired cognitive functioning. The relative
contributions of different etiological factors, such as alcohol, thiamine deficiency and age …

[HTML][HTML] Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study

JW Kim, MS Byun, D Yi, JH Lee, K Ko, SY Jeon… - PLoS …, 2020 - journals.plos.org
Background An emerging body of literature has indicated that moderate alcohol intake may
be protective against Alzheimer disease (AD) dementia. However, little information is …

Ethanol alters APP processing and aggravates Alzheimer-associated phenotypes

D Huang, M Yu, S Yang, D Lou, W Zhou, L Zheng… - Molecular …, 2018 - Springer
The majority of Alzheimer's disease (AD) cases are sporadic with unknown causes. Many
dietary factors including excessive alcohol intake have been reported to increase the risk to …

Cognitive decline and recovery in alcohol abuse

CJ Perry - Journal of molecular neuroscience, 2016 - Springer
Alcohol consumption triggers a neuroinflammatory response which, if prolonged, can lead to
substantial volume loss in both gray and white matter. This brain injury is associated with …

[HTML][HTML] Autophagy alleviates ethanol-induced memory impairment in association with anti-apoptotic and anti-inflammatory pathways

Y Liu, Y Zhang, J Peng, H Wang, X Li, X Li… - Brain, Behavior, and …, 2019 - Elsevier
Chronic excessive drinking leads to a wide spectrum of neurological disorders, including
cognitive deficits, such as learning and memory impairment. However, the neurobiological …