The phosphorylation state of Retinoblastoma protein (Rb) plays a role in cell proliferation
and apoptosis. Within cells, cyclin dependent kinases (cdks) phosphorylate Rb in response …

There is abundant evidence that Retinoblastoma (Rb) activity is important in the control of
cell proliferation and apoptosis. Reversible phosphorylation of the Rb protein that is carried …

ABSTRACT The tumor suppressor Retinoblastoma (Rb) protein is highly phosphorylated in
cancer cells largely due to the overexpression of cyclins or the loss of expression of cyclin …

The serine/threonine protein phosphatase 1 (PP1) dephosphorylates hundreds of key
biological targets by associating with nearly 200 regulatory proteins to form highly specific …

Downregulation of the Phosphatase Nuclear Targeting Subunit (PNUTS) triggers pRB
dephosphorylation and apoptosis in pRB positive Page 1 842 Cancer Biology & Therapy 2008; …

Abstract Seliciclib (CYC202, R-Roscovitine) is a 2, 6, 9-substituted purine analog that is
currently in phase II clinical trials as an anticancer agent. We show in this study that R …

Roscovitine, a cyclin-dependent kinases (CDKs) inhibitor, has been reported to have anti-
tumor effects in some cancer cell lines by inducing apoptosis. However, the exact underlying …

Roscovitine has been reported to have anti-tumor effects in some cancer cell lines. The
phosphatidylinositol-3-kinase (PI3K) signaling, which activates protein kinase B (PKB)/Akt, is …

Chemical inhibitors of cyclin-dependent kinase (CDK), like roscovitine, are promising drugs
in the context of new cancer therapies. Roscovitine and related compounds, like seliciclib …

Previously we found that retinoblastoma protein (RB) became dephosphorylated in an early
stage of DNA damage-induced, p53-independent apoptosis. Here, we report that both RB …