The receptive part of the primary afferent axon is most vulnerable to systemic capsaicin in adult rats

K Chung, CM Klein, RE Coggeshall - Brain research, 1990 - Elsevier
The present study shows that systemic capsaicin in adult rats results in a significant loss of
axons in the subepidermal nerve plexus of the posterior leg but no loss of axons in the sural …

Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat

G Jancso, E Király, F Joo, G Such, A Nagy - Neuroscience letters, 1985 - Elsevier
The morphological effects of systemic capsaicin treatment have been studied in adult rats.
Light and electron microscopy revealed that a subpopulation of small-to-medium sized B …

The immediate and long-term effects of applying capsaicin to cutaneous nerves.

B Lynn - Acta Physiologica Hungarica, 1987 - europepmc.org
Capsaicin has now been shown to have a neurotoxic action on C-fibres in adult rodents and
several other mammalian species. In the adult the effect is preferentially on nociceptive C …

The acute effects of capsaicin on rat primary afferents and spinal neurons

JT Williams, W Zieglagänsberger - Brain research, 1982 - Elsevier
Capsaicin applied to the soma of fast and slow conducting primary afferent fibers had a
depolarizing action associated with an increase in membrane conductance. The …

Effects of capsaicin applied locally to adult peripheral nerve. I. Physiology of peripheral nerve and spinal cord

PD Wall, M Fitzgerald - Pain, 1981 - journals.lww.com
Systemic capsaicin treatment of neonatal and adult rats is known to affect unmyelinated
afferents. However, the systemic route of administration presents several disadvantages and …

Capsaicin's action on the nervous system

JI Nagy - Trends in Neurosciences, 1982 - cell.com
Over the past several decades capsaicin, a natural product of certain species of red pepper,
has been found to have a broad range of physiological effects in adult animals. Recent …

Characterization of the peptide and sensory neurotoxic effects of capsaicin in the guinea pig

SH Buck, JH Walsh, TP Davis, MR Brown… - Journal of …, 1983 - Soc Neuroscience
The effects of capsaicin, the major pungent ingredient of hot peppers, were assessed on
sensory neuron neuropeptide levels and on sensory function in the adult guinea pig …

The time course and specificity of the changes in the behavioural and dorsal horn cell responses to noxious stimuli following peripheral nerve capsaicin treatment in …

M Fitzgerald, CJ Woolf - Neuroscience, 1982 - Elsevier
Capsaicin, a neurotoxin which acts specifically on sensory primary afferent C-fibres was
applied locally to one sciatic nerve of a group of rats. One to sixteen days following this a …

Effects of capsaicin applied locally to adult peripheral nerve. II. Anatomy and enzyme and peptide chemistry of peripheral nerve and spinal cord

A Ainsworth, P Hall, PD Wall, G Allt, LM MacKenzie… - Pain, 1981 - journals.lww.com
EFFECTS OF CAPSAICIN APPLIED LOCALLY TO ADULT PERIPHERAL NERVE. II.
ANATOMY AND ENZYME AND PEPTIDE CHEMISTRY OF PERIPHERAL NERVE Page 1 P&t …

Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat

JI Nagy, LL Iversen, M Goedert… - Journal of …, 1983 - Soc Neuroscience
The numbers of myelinated and unmyelinated fibers were counted in dorsal roots of adult
rats treated neonatally with capsaicin in doses ranging from 5 to 100 mg/kg. Substance P …