Abstract Sirtuin1 (SIRT1) belongs to the mammalian sirtuin family and plays an important
role in deacetylating histones and non-histones. SIRT1 is associated with tumor metastasis …

Background SIRT1 is a member of the mammalian sirtuin family with the ability to
deacetylate histone and nonhistone proteins. The correlation between SIRT1 expression …

SIRT1 belongs to the mammalian sirtuin family and plays an important role in deacetylating
histone and nonhistone proteins. It is reported that SIRT1 is associated with tumor …

The mammalian homolog of yeast Sir2 protein is the sirtuin family of histone deacetylases
(HDACs), a NAD+-dependent protein deacetylase in humans. Accumulating evidence …

EMT is a pivotal mechanism involved in tumor metastasis, which is the leading cause of poor
prognosis for hepatocellular carcinoma (HCC). Sirtuin family members function as NAD+ …

Background High expression of Sirtuin type 1 (SIRT1) exists in some cancer cells. However,
it is still unclear whether SIRT1 affects the sensitivity of esophageal cancer cells to cisplatin …

Abstract Sirtuin-1 (SIRT1), one member of the mammalian sirtuin family, has been
suggested to play an essential role in the development and progression of many tumors …

We aimed to evaluate the influence of sirtuin1 (sirt1) on the ESCC chemotherapeutic
sensitivity to cisplatin. We used ESCC cell ablation sirt1 for establishing a xenograft mouse …

ABSTRACT Introduction Sirtuin 1 (SIRT1) is a key modulator in several types of cancer,
including colorectal cancer (CRC). Here, we probed into the molecular mechanism of SIRT1 …

Melanoma is highly metastatic, and understanding of its molecular mechanism is urgently
needed for the development of therapeutic targets and prognostic assessment for metastatic …