Alzheimer's disease (AD) is the most common cause of cognitive impairment in older
patients and is expected to increase greatly in prevalence in the next future. It is …

Alzheimer's disease (AD) is the major cause of late-life brain failure. In the past 25 years,
autosomal dominant forms of AD were found to be primariy attributable to mutations in one …

Alzheimer's disease (AD) is the most common cause of dementia and accounts for one-half
to three-fourths of all cases of dementia. In the United States, AD is the leading cause of a …

Background The aggregation of amyloid-β (Aβ) into insoluble plaques is a hallmark
pathology of Alzheimer's disease (AD). Previous work has shown increasing serotonin …

Alzheimer's disease (AD) is a progressive neurodegenerative disease which begins with
insidious deterioration of higher cognition and progresses to severe dementia. Clinical …

Amyloid β (Aβ) accumulation is considered the main culprit in the pathogenesis of
Alzheimer's disease (AD). Recent studies suggest that decreasing Aβ production at very …

Objective Research on the efficacy of antidepressant therapy for depressive symptoms in
Alzheimer disease has been hampered by lack of systematic diagnosis, small sample sizes …

Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Alzheimer's disease (AD) is the leading neurodegenerative cause of dementia in the elderly.
Thus far, there is no curative treatment for this devastating condition, thereby creating …

Alzheimer's disease (AD) drug developments and clinical trials (CT) remain vulnerable to
problems that undermine research validity. Investigations of CT methods reveal how …