Several lines of evidence suggest that the aetio-pathogenesis of the common form of type 2
diabetes mellitus and its intrinsically related features of impaired insulin secretion and …

OBJECTIVE—The majority of type 1 diabetes is considered to be autoimmune with, for the
most part, abrupt development. However, type 1 diabetes with slow onset, or the so-called …

Aims Diagnostic screening of NEUROD1 in patients with maturity‐onset diabetes of the
young (MODY) without mutations in the known MODY‐genes (MODYX) and in subjects …

Aims/hypothesis. The identification of mutations in hepatocyte nuclear factors-1α,–4α,–1 β
and insulin promoter factor-1 in maturity onset diabetes of the young (MODY) has …

Aim: To evaluate the frequency of known polymorphisms in the exon 2 of the NeuroD1 gene
and in the interleukin (IL)-18 promoter region in patients with type 1 diabetes mellitus …

Objective: In contrast to the most commonly reported forms of maturity-onset diabetes of the
young (MODY), including MODY2, MODY3 and MODY5, MODY6 is a relatively rare subtype …

Background and aims: Type 2 diabetes (T2D) is a complex polygenic disorder. Various
genome wide scans have identified different loci in linkage to T2D; yet, a major locus still …

Aims Modulation of dopamine receptor D2 (DRD 2) activity affects insulin secretion in both
rodents and isolated pancreatic β‐cells. We hypothesized that single nucleotide …

Aims Only a few families with neuronal differentiation 1 (NEUROD1)‐deficient diabetes,
currently designated as maturity‐onset diabetes of the young 6 (MODY6), have been …

The helix-loop-helix (HLH) protein NEUROD1 (also known as BETA2) functions as a
regulatory switch for endocrine pancreatic development. In mice homozygous for a targeted …