The molecular and cellular mechanisms underlying the pathogenesis of chronic obstructive
pulmonary disease (COPD) remain incompletely understood. We have investigated the …

Autophagy serves a critical function in cellular homeostasis by prolonging survival during
nutrient deprivation. Although primarily characterized as a cell survival mechanism, the …

Autophagy is a cellular process for the disposal of damaged organelles or denatured
proteins through a lysosomal degradation pathway. By reducing endogenous …

Autophagy is a process of lysosomal self-degradation that helps to maintain the homeostatic
balance between the synthesis, degradation and recycling of cellular proteins and …

(Macro) autophagy provides a membrane-dependent mechanism for the sequestration,
transport, and lysosomal turnover of subcellular components, including proteins and …

The development of chronic lung disease occurs as a consequence of multiple cellular
events that involve an initial insult which often leads to the development of chronic …

Chronic obstructive pulmonary disease (COPD) is a common lung disease characterised by
progressive, irreversible airflow limitation. Multiple regulatory pathways are involved in …

Autophagy (or macroautophagy) is a key cellular process that removes damaged molecules
(particularly proteins) and subcellular organelles to maintain cellular homeostasis. There is …

Background There is increasing evidence of autophagy activation in COPD, but its role is
complex and probably regulated through cell type-specific mechanisms. This study aims to …

The pathogenesis of pulmonary diseases is often complex and characterized by multiple
cellular events, including inflammation, cell death, and cell proliferation. The mechanisms by …