DNA methylation is known as a universal mechanism of epigenetic regulation in all
kingdoms of life. Particularly, given that prokaryotes lack key elements such as histones and …

The amount of bacterial and archaeal genome sequence and methylome data has greatly
increased over the last decade, enabling new insights into the functional roles of DNA …

Epigenetics modulates expression levels of various important genes in both prokaryotes and
eukaryotes. These epigenetic traits are heritable without any change in genetic DNA …

Highlights•Bacterial genomes contain C 5-methyl-cytosine, N 4-methyl-cytosine, and N 6-
methyl-adenine.•Base methylation controls DNA–protein interactions.•DNA methylation …

In prokaryotes, alteration in gene expression was observed with the modification of DNA,
especially DNA methylation. Such changes are inherited from generation to generation with …

Epigenetics is a change in gene expression that is heritable without a change in DNA
sequence itself. This phenomenon is well studied in eukaryotes, particularly in humans for …

Formation of C5-methylcytosine, N4-methylcytosine, and N6-methyladenine in bacterial
genomes is postreplicative and involves transfer of a methyl group from S-adenosyl …

Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic
changes play a key role in the immune response to bacteria, among which DNA …

The presence of post-replicative DNA methylation is pervasive among both prokaryotic and
eukaryotic organisms. In bacteria, the study of DNA methylation has largely been in the …

An increasing number of studies have reported that bacterial DNA methylation has important
functions beyond the roles in restriction-modification systems, including the ability of …