The importance of the ubiquitin system largely depends on ubiquitin ligases, E3s, as they
determine the specificity of the system. Rbx1/ROC1/Hrt1, a RING finger protein, functions as …

Protein ubiquitination plays an important role in regulating the abundance and conformation
of a broad range of eukaryotic proteins. This process involves a cascade of enzymes …

Cul1 and Cul7 are cullin E3 ubiquitin ligase scaffold proteins. Cul1 is known to form a
complex with the RING domain protein Rbx1 and one of approximately 70 different F-box …

Cullins are members of a family of scaffold proteins that assemble multisubunit ubiquitin
ligase complexes to confer substrate specificity for the ubiquitination pathway. Cullin3 (Cul3) …

Cullin-based E3 ligases are a large family of multi-subunit ubiquitin ligases with diverse
cellular functions, including the regulation of the cell cycle, of the DNA damage response …

Cullin-based E3 ligases are a large family of ubiquitin ligases with diverse cellular functions.
They are composed of one of six mammalian cullin homologues, the Ring finger containing …

The Elongin BC-box protein family includes the von Hippel-Lindau tumor suppressor and
suppressor of cytokine signaling proteins, which are substrate recognition subunits of …

Cullin E3 ligases are the largest family of ubiquitin ligases with diverse cellular functions.
One of seven cullin proteins serves as a scaffold protein for the assembly of the multisubunit …

The RING-H2 finger protein Rbx1 is a subunit of the related SCF (S kp1–C dc53/Cul1–F-box
protein) and von Hippel-Lindau (VHL) tumor suppressor (elongin BC–Cul2–VHL) E3 …

Cullin-RING ubiquitin ligases (CRLs) represent the largest family of E3 ubiquitin ligases that
control most if not all cellular processes. In CUL3-based CRLs, the substrate specificity is …