Sialic acid mimetics to target the sialic acid–Siglec axis

C Büll, T Heise, GJ Adema, TJ Boltje - Trends in biochemical sciences, 2016 - cell.com
Sialic acid sugars are vital regulators of the immune system through binding to
immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on …

Steering Siglec–sialic acid interactions on living cells using bioorthogonal chemistry

C Büll, T Heise, N van Hilten… - Angewandte Chemie …, 2017 - Wiley Online Library
Sialic acid sugars that terminate cell‐surface glycans form the ligands for the sialic acid
binding immunoglobulin‐like lectin (Siglec) family, which are immunomodulatory receptors …

Modulation of immune tolerance via siglec-sialic acid interactions

J Lübbers, E Rodríguez, Y Van Kooyk - Frontiers in immunology, 2018 - frontiersin.org
One of the key features of the immune system is its extraordinary capacity to discriminate
between self and non-self and to respond accordingly. Several molecular interactions allow …

Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation

LD Movsisyan, MS Macauley - Organic & biomolecular chemistry, 2020 - pubs.rsc.org
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are transmembrane proteins of the
immunoglobulin (Ig) superfamily predominantly expressed on the cells of our immune …

Current status on therapeutic molecules targeting Siglec receptors

MP Lenza, U Atxabal, I Oyenarte, J Jiménez-Barbero… - Cells, 2020 - mdpi.com
The sialic acid-binding immunoglobulin-type of lectins (Siglecs) are receptors that recognize
sialic acid-containing glycans. In the majority of the cases, Siglecs are expressed on …

[HTML][HTML] Sialic acid and biology of life: An introduction

S Ghosh - Sialic acids and sialoglycoconjugates in the biology of …, 2020 - ncbi.nlm.nih.gov
Sialic acids are important molecule with high structural diversity. They are known to occur in
higher animals such as Echinoderms, Hemichordata, Cephalochorda, and Vertebrata and …

Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs

SJ Moons, GJ Adema, MTGM Derks, TJ Boltje… - …, 2019 - academic.oup.com
Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved
in a multitude of biological processes and aberrant sialic acid expression is associated with …

Sweet escape: sialic acids in tumor immune evasion

C Büll, MH den Brok, GJ Adema - … et Biophysica Acta (BBA)-Reviews on …, 2014 - Elsevier
Sialic acids represent a family of sugar molecules derived from neuraminic acid that
frequently terminate glycan chains and contribute to many biological processes. Already five …

Sialic acid-siglec axis in human immune regulation, involvement in autoimmunity and cancer and potential therapeutic treatments

E Gianchecchi, A Arena, A Fierabracci - International Journal of …, 2021 - mdpi.com
Siglecs are sialic acid-binding immunoglobulin-like lectins. Most Siglecs function as
transmembrane receptors mainly expressed on blood cells in a cell type-specific manner …

Multivalent sialic acid materials for biomedical applications

Y Cao, W Song, X Chen - Biomaterials Science, 2023 - pubs.rsc.org
Sialic acid is a kind of monosaccharide expressed on the non-reducing end of glycoproteins
or glycolipids. It acts as a signal molecule combining with its natural receptors such as …