Sialic acid mimetics to target the sialic acid–Siglec axis
Sialic acid sugars are vital regulators of the immune system through binding to
immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on …
immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on …
Steering Siglec–sialic acid interactions on living cells using bioorthogonal chemistry
Sialic acid sugars that terminate cell‐surface glycans form the ligands for the sialic acid
binding immunoglobulin‐like lectin (Siglec) family, which are immunomodulatory receptors …
binding immunoglobulin‐like lectin (Siglec) family, which are immunomodulatory receptors …
Modulation of immune tolerance via siglec-sialic acid interactions
J Lübbers, E Rodríguez, Y Van Kooyk - Frontiers in immunology, 2018 - frontiersin.org
One of the key features of the immune system is its extraordinary capacity to discriminate
between self and non-self and to respond accordingly. Several molecular interactions allow …
between self and non-self and to respond accordingly. Several molecular interactions allow …
Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation
LD Movsisyan, MS Macauley - Organic & biomolecular chemistry, 2020 - pubs.rsc.org
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are transmembrane proteins of the
immunoglobulin (Ig) superfamily predominantly expressed on the cells of our immune …
immunoglobulin (Ig) superfamily predominantly expressed on the cells of our immune …
Current status on therapeutic molecules targeting Siglec receptors
MP Lenza, U Atxabal, I Oyenarte, J Jiménez-Barbero… - Cells, 2020 - mdpi.com
The sialic acid-binding immunoglobulin-type of lectins (Siglecs) are receptors that recognize
sialic acid-containing glycans. In the majority of the cases, Siglecs are expressed on …
sialic acid-containing glycans. In the majority of the cases, Siglecs are expressed on …
[HTML][HTML] Sialic acid and biology of life: An introduction
S Ghosh - Sialic acids and sialoglycoconjugates in the biology of …, 2020 - ncbi.nlm.nih.gov
Sialic acids are important molecule with high structural diversity. They are known to occur in
higher animals such as Echinoderms, Hemichordata, Cephalochorda, and Vertebrata and …
higher animals such as Echinoderms, Hemichordata, Cephalochorda, and Vertebrata and …
Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs
SJ Moons, GJ Adema, MTGM Derks, TJ Boltje… - …, 2019 - academic.oup.com
Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved
in a multitude of biological processes and aberrant sialic acid expression is associated with …
in a multitude of biological processes and aberrant sialic acid expression is associated with …
Sweet escape: sialic acids in tumor immune evasion
C Büll, MH den Brok, GJ Adema - … et Biophysica Acta (BBA)-Reviews on …, 2014 - Elsevier
Sialic acids represent a family of sugar molecules derived from neuraminic acid that
frequently terminate glycan chains and contribute to many biological processes. Already five …
frequently terminate glycan chains and contribute to many biological processes. Already five …
Sialic acid-siglec axis in human immune regulation, involvement in autoimmunity and cancer and potential therapeutic treatments
E Gianchecchi, A Arena, A Fierabracci - International Journal of …, 2021 - mdpi.com
Siglecs are sialic acid-binding immunoglobulin-like lectins. Most Siglecs function as
transmembrane receptors mainly expressed on blood cells in a cell type-specific manner …
transmembrane receptors mainly expressed on blood cells in a cell type-specific manner …
Multivalent sialic acid materials for biomedical applications
Y Cao, W Song, X Chen - Biomaterials Science, 2023 - pubs.rsc.org
Sialic acid is a kind of monosaccharide expressed on the non-reducing end of glycoproteins
or glycolipids. It acts as a signal molecule combining with its natural receptors such as …
or glycolipids. It acts as a signal molecule combining with its natural receptors such as …