Activation of the mineralocorticoid receptor (MR) in the distal nephron by its ligand,
aldosterone, plays an important role in sodium reabsorption and blood pressure regulation …

Accumulating evidence has indicated the potential contributions of aldosterone and
mineralocorticoid receptor (MR) to the pathophysiology of cardiovascular disease (CVD) …

Background: The remarkable success of clinical trials in mineralocorticoid receptor (MR)
inhibition in heart failure has driven research on the physiological and pathological role (s) …

The mineralocorticoid receptor (MR), a member of the steroid receptor family, regulates
blood pressure by mediating the effects of the hormone aldosterone (Aldo) on renal sodium …

The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

For 50years aldosterone has been thought to act primarily on epithelia to regulate fluid and
electrolyte homeostasis. Mineralocorticoid receptors (MR), however, are also expressed in …

Aldosterone controls salt–water homeostasis by acting on the mineralocorticoid receptor
(MR), a ligand-activated transcription factor, in kidney epithelial cells. However, it is now …

Background: A full understanding of the mechanisms of action of aldosterone and its
interaction with the mineralocorticoid receptor (MR) allows a theoretical framework to predict …

Slowing the progression of chronic kidney diseases (CKDs) requires new and effective
treatment approaches. Aldosterone classically acts on the distal nephron: it facilitates …

In the review we discuss the role of mineralocorticoid receptors (MRs) in regulation and
pathological remodelling of the cardiovascular system and the therapeutic potential of …