CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in
the 1970s. This is because of its involvement in the metabolism of more than 25% of the …

CYP2D6 is of great importance for the metabolism of clinically used drugs and about 20–
25% of those are metabolised by this enzyme. In addition, the enzyme utilises …

CYP2D6 is polymorphically distributed and is responsible for the metabolism of several
clinically important drugs. It is also related to several pathophysiological conditions. Defect …

Polymorphisms in the cytochrome P450 2D6 (CYP2D6) gene are a major cause of
pharmacokinetic variability in human. Although the poor metabolizer phenotype is known to …

The aim of the present study was to determine the prevalence of the most common allelic
variants of the polymorphic cytochrome P450 (CYP) enzymes CYP2D6, CYP2C9, CYP2C19 …

Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~
20% of commonly used drugs across a broad spectrum of medical disciplines including …

Cytochrome P450 2D6 (CYP2D6) is an enzyme of potential importance for the metabolism
of drugs used clinically, and it exhibits genetic polymorphism with interindividual differences …

The polymorphic cytochrome P450 CYP2D6 is involved in the metabolism of various drugs
of wide therapeutic use and is a presumed susceptibility factor for certain environmentally …

Published studies demonstrate that significant ethnic differences can exist in the metabolism
of some drugs. These differences are caused by cytochrome P450 polymorphisms and …

The CYP2D6 gene encodes an enzyme important in the metabolism of many commonly
used medications. Variation in CYP2D6 is associated with inter-individual differences in …