Patients with homozygous familial hypercholesterolaemia (HoFH) have markedly elevated
low density lipoprotein (LDL) cholesterol levels that are refractory to standard doses of lipid …

We have compared the effects of lovastatin and simvastatin on plasma lipoproteins,
fibrinogen and urinary mevalonic acid excretion in twenty-three patients with heterozygous …

Patients with homozygous familial hypercholesterolaemia (HFH) have abnormalities in both
low-density lipoprotein (LDL) receptor alleles, resulting in severe hypercholesterolaemia …

The effects of lovastatin, an inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase
(HMG CoA reductase), on 24-hour urinary excretion rates of mevalonic acid (an intermediate …

We have examined the influence of simvastatin, a competitive inhibitor of 3‐hydroxy‐3‐
methyl glutaryl coenzyme A reductase on plasma concentrations of lipids and lipoproteins …

The efficacy of atorvastatin, a new hydroxymethylglutaryl (HMG)-CoA reductase inhibitor, in
reducing serum lipid levels, modifying lipoprotein composition, and suppressing cholesterol …

HMG-CoA reductase inhibitors or statins are effective in both the primary and secondary
prevention of coronary heart disease, the extent of benefit being proportional to the …

The hypocholesterolaemic effect of pravastatin 40 mg and lovastatin 40 mg daily has been
compared in patients with familial hypercholesterolaemia (FH). Administration of the two …

Apheresis only partially controls raised low density lipoprotein cholesterol levels in patients
with homozygous familial hypercholesterolemia, who usually respond poorly to lipid …

The effects of atorvastatin (Lipitor®) were evaluated in 40 patients with familial
hypercholesterolemia (FH). Following a 6 week drug-free baseline period 20 male and 20 …