The Hedgehog (Hh) signaling pathway is correlated with hepatic stellate cells (HSCs)
activation and liver fibrosis. Gli2 is a key transcription effector of Hh signaling. However, the …

Background and Purpose Portal hypertension is a lethal complication of cirrhosis. Its
mechanism and therapeutic targets remain largely unknown. Hepatic stellate cell (HSC) …

Objectives: Emerging evidence indicates that Wnt/β-catenin pathway is linked to the fibrosis
of different organs including liver fibrosis. β-Catenin promotes hepatic stellate cells (HSCs) …

Hepatic fibrosis (HF) is a self-healing pathological process after all kinds of chronic liver
injuries and can cause diseases such as liver cirrhosis and liver cancer. The Wnt signaling …

Aims We tested whether transforming growth factor β1 (TGF-β1) signaling plays an important
role in hepatic stellate cell differentiation fate and investigated the role of Jagged1/Notch in …

Hepatic stellate cells (HSCs), the pluripotent cells, exist between liver sinusoidal endothelial
cells and hepatic epithelial cells. Activated HSCs transform to myofibroblast-like cells, start to …

Progressive liver fibrosis is a dynamic process characterized by the net accumulation of
extracellular matrix (ECM), which could eventually develop into cirrhosis, leading to …

Background and Aims Depletion of hepatic stellate cells (HSCs) was shown to protect the
liver from acute injury due to ischemia/reperfusion and concanavalin A. Depletion protocol …

Recent research on hepatic stellate cells (HSCs) has spotlighted the involvement of
morphogens in their cell fate determination in liver fibrosis. Temporally and spatially …

Methods The global transcript levels in platelet derived growth factor-BB (PDGF-BB)-
stimulated hTERT HSCs were analyzed using oligonucleotide microarrays. Oligonucleotide …