B cells can promote liver fibrosis, but the mechanism of B cell infiltration and therapy against
culprit B cells are lacking. We postulated that the disruption of cholangiocyte-B-cell crosstalk …

Hepatic stellate cells, which reside in the space of Disse in close contact with both
sinusoidal endothelial cells and hepatocytes, play multiple roles in the pathophysiology of …

Abstract Purpose Hepatic stellate cells (HSCs) transdifferentiate to become extracellular
matrix-producing myofibroblasts during liver injury. Myofibroblasts can also promote …

Background: Activated hepatic stellate cells (aHSCs) regulate the function of immune cells
during liver fibrosis. As major innate cells in the liver, macrophages have inducible plasticity …

Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix
(ECM) in the liver resulting from the persistent liver injury and wound-healing reaction …

Objectives Emerging evidence indicates that Wnt/β-catenin pathway is linked to the fibrosis
of different organs including liver fibrosis. β-Catenin promotes hepatic stellate cells (HSCs) …

Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …

Liver fibrosis has a complex pathogenesis and involves various intracellular and
extracellular signal transduction pathways, but its specific pathogenesis remains unclear …

Hepatic stellate cells (HSCs) are key players in liver fibrosis and regeneration via collagen
degradation and synthesis. These phenomena involve inflammatory cytokines released from …

Objective To observe the effects of Wnt3a on proliferation and, activation of hepatic stellate
cells (HSCs) and their the expression of the transforming growth factor beta (TGFb) …