Background: Liver cancer is a major medical problem because of its high morbidity and
mortality. Hepatocellular carcinoma (HCC) is the most common type of liver cancer …

Biophysical protein-protein interactions perform dominant roles in the initiation and
progression of many cancer-related pathways. A protein-protein interaction might play …

As cancer is a complex disease, the representation of a malignant cell as a protein-protein
interaction network (PPIN) and its subsequent analysis can provide insight into the …

This study aimed to select the feature genes of hepatocellular carcinoma (HCC) with the
Fisher score algorithm and to identify hub genes with the Maximal Clique Centrality (MCC) …

Biological pathways play important roles in the development of complex diseases, such as
cancers, which are multifactorial complex diseases that are usually caused by multiple …

Background One challenge facing biologists is to tease out useful information from massive
data sets for further analysis. A pathway-based analysis may shed light by projecting …

Abstract Objective Incidence of both Type 2 diabetes mellitus (T2DM) and hepatocellular
carcinoma (HCC) are rapidly increasing worldwide. One of the leading causes of HCC is …

Abstract Chronic Infection of Hepatitis B virus (HBV) is one risk factor of hepatocellular
carcinoma (HCC). Much effort has been made to research the process of HBV-associated …

Identification of disease-causing genes among a large number of candidates is a
fundamental challenge in human disease studies. However, it is still time-consuming and …

Background Hepatocellular carcinoma (HCC), the main type of liver cancer in human, is one
of the most prevalent and deadly malignancies in the world. The present study aimed to …