Methodology of predicting novel key regulators in ovarian cancer network: a network theoretical approach

MZ Malik, K Chirom, S Ali, R Ishrat, P Somvanshi… - BMC cancer, 2019 - Springer
Background Identification of key regulator/s in ovarian cancer (OC) network is important for
potential drug target and prevention from this cancer. This study proposes a method to …

Integrated bioinformatic analysis identifies networks and promising biomarkers for hepatitis B virus‐related hepatocellular carcinoma

Y Ji, Y Yin, W Zhang - International Journal of Genomics, 2020 - Wiley Online Library
Chronic infection with hepatitis B virus (HBV) has long been recognized as a dominant
hazard factor for hepatocellular carcinoma (HCC) and accounts for at least half of HCC …

Identification of human disease genes from interactome network using graphlet interaction

XD Wang, JL Huang, L Yang, DQ Wei, YX Qi, ZL Jiang - PloS one, 2014 - journals.plos.org
Identifying genes related to human diseases, such as cancer and cardiovascular disease,
etc., is an important task in biomedical research because of its applications in disease …

[HTML][HTML] Bioinformatics analysis of key biomarkers and potential molecular mechanisms in hepatocellular carcinoma induced by hepatitis B virus

Z Li, J Xu, H Cui, J Song, J Chen, J Wei - Medicine, 2020 - journals.lww.com
Background: Hepatocellular carcinoma (HCC) accounts for up to 90% of all primary hepatic
malignancies; it is the sixth most common cancer and the second most common cause of …

A multi-method approach for proteomic network inference in 11 human cancers

Y Şenbabaoğlu, SO Sümer… - PLoS computational …, 2016 - journals.plos.org
Protein expression and post-translational modification levels are tightly regulated in
neoplastic cells to maintain cellular processes known as 'cancer hallmarks'. The first Pan …

[HTML][HTML] Introducing crucial protein panel of gastric adenocarcinoma disease

M Rezaei-Tavirani, M Rezaei-Tavirani… - … and Hepatology from …, 2017 - ncbi.nlm.nih.gov
Aim: Since interactome analysis of diseases can provide candidate biomarker panel related
to the diseases, in this research, protein-protein interaction (PPI) network analysis is used to …

Graph-theoretical comparison reveals structural divergence of human protein interaction networks

ME Futschik, A Tschaut, G Chaurasia… - Genome Informatics, 2007 - jstage.jst.go.jp
Protein interactions constitute the backbone of the cellular machinery in living systems. Their
biological importance has led to systematic assemblies of large-scale protein-protein …

Prognostic genes of hepatocellular carcinoma based on gene coexpression network analysis

B Xu, W Lv, X Li, L Zhang, J Lin - Journal of cellular …, 2019 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most common subtype in liver cancer whose
prognosis is affected by malignant progression associated with complex gene interactions …

Computational discovery of Epstein-Barr virus targeted human genes and signalling pathways

S Mei, K Zhang - Scientific reports, 2016 - nature.com
Epstein-Barr virus (EBV) plays important roles in the origin and the progression of human
carcinomas, eg diffuse large B cell tumors, T cell lymphomas, etc. Discovering EBV targeted …

A computational method based on the integration of heterogeneous networks for predicting disease-gene associations

X Guo, L Gao, C Wei, X Yang, Y Zhao, A Dong - PloS one, 2011 - journals.plos.org
The identification of disease-causing genes is a fundamental challenge in human health
and of great importance in improving medical care, and provides a better understanding of …