Within the past decade, the field of immunotherapy has revolutionized the treatment of many
cancers with the development and regulatory approval of various immune-checkpoint …

The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are
recognized by autologous T cells in the host. As neoepitopes are not subject to central …

Simple Summary Personalized neoantigen vaccines are a diverse group of personally
tailored cancer vaccines that strengthen patients´ own immune reaction against cancer …

Despite years of preclinical efforts and hundreds of clinical studies, therapeutic cancer
vaccines with the routine ability to limit or eliminate tumor growth in humans have been …

Neoantigens arise from somatic mutations that differ from wild-type antigens and are specific
to each individual patient, which provide tumor specific targets for developing personalized …

Immunotherapy treatments harnessing the immune system herald a new era of personalized
medicine, offering considerable benefits for cancer patients. Over the past years, tumor …

During their development and progression tumors acquire numerous mutations that, when
translated into proteins give rise to neoantigens that can be recognized by T cells. Initially …

Genetic instability of tumor cells often leads to the occurrence of a large number of
mutations, and expression of non-synonymous mutations can produce tumor-specific …

Cancer vaccines, which are designed to amplify tumour-specific T cell responses through
active immunization, have long been envisioned as a key tool of effective cancer …