In the present study, we examined the effect of metyrapone, an inhibitor of corticosterone
(CS) synthesis, on the behavioral and neurochemical sequelae induced by a brief restraint …

The extent to which the hypothalamic–pituitary–adrenal axis is activated by short-term and
long-term consequences of stress is still open to investigation. This study aimed to …

Metyrapone is a glucocorticoid synthesis inhibitor known to induce a stress-like biological
syndrome, but also to limit stress-related behaviours. Since stress is usually associated to an …

Prior research has demonstrated that diazepam decreases hypothalamic-pituitary-adrenal
cortex (HPA) axis activity in stressful contexts but, paradoxically, acts as a stimulator of basal …

In previous studies, we have shown that male Wistar rats exposed to a single inescapable
stressor session (15 min restraint) exhibited 24 h later an anxiogenic-like behavior in the …

Depressive disorder involves emotional, cognitive, autonomic and endocrine alterations and
also evidences support the role of stress in the development of this disorder. Because the …

Although stress is an extensively investigated phenomenon, the effects of specific stressors
on the pharmacologic activity of routinely administered drugs are less well characterized …

Chronic stress facilitates fear conditioning in rats with hippocampal neuronal atrophy and in
rats in which the atrophy is prevented with tianeptine, a serotonin re-uptake enhancer. The …

Inescapable shock (IS) exposure induces behavioral inactivity, related to behavioral
alterations in subsequent tests (ie, escape failure, and inactivity during shuttle box task) …

Mild traumatic brain injuries (TBIs) comprise three-quarters of all TBIs occurring in the United
States annually, and psychological symptoms arising from them can last years after injury …