Cell competition: emerging signaling and unsolved questions
R Nagata, T Igaki - FEBS letters, 2024 - Wiley Online Library
Multicellular communities have an intrinsic mechanism that optimizes their structure and
function via cell–cell communication. One of the driving forces for such self‐organization of …
function via cell–cell communication. One of the driving forces for such self‐organization of …
Cell competition: how to eliminate your neighbours
M Amoyel, EA Bach - Development, 2014 - journals.biologists.com
A conventional view of development is that cells cooperate to build an organism. However,
based on studies of Drosophila, it has been known for years that viable cells can be …
based on studies of Drosophila, it has been known for years that viable cells can be …
[HTML][HTML] Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α
N Ochi, M Nakamura, R Nagata, N Wakasa… - PLoS …, 2021 - journals.plos.org
Cell competition is a context-dependent cell elimination via cell-cell interaction whereby unfit
cells ('losers') are eliminated from the tissue when confronted with fitter cells ('winners') …
cells ('losers') are eliminated from the tissue when confronted with fitter cells ('winners') …
Picking winners and losers: cell competition in tissue development and homeostasis
W Kim, R Jain - Trends in Genetics, 2020 - cell.com
Viable cells with reduced fitness are often eliminated by neighboring cells with greater
fitness. This phenomenon, called cell competition, is an important mechanism for …
fitness. This phenomenon, called cell competition, is an important mechanism for …
Loss of Rer1 causes proteotoxic stress that drives cell competition and inhibits Myc-driven overgrowth
PK Paul, W Annaert, V Chaudhary - bioRxiv, 2022 - biorxiv.org
Cell competition is a developmental phenomenon that allows the selection of healthier cells
in a developing tissue. In this process, cells with reduced fitness, conceivably due to harmful …
in a developing tissue. In this process, cells with reduced fitness, conceivably due to harmful …
Emerging mechanisms of cell competition
NE Baker - Nature Reviews Genetics, 2020 - nature.com
The growth and survival of cells within tissues can be affected by 'cell competition'between
different cell clones. This phenomenon was initially recognized between wild-type cells and …
different cell clones. This phenomenon was initially recognized between wild-type cells and …
New frontiers in cell competition
Cellular communication is at the heart of animal development, and guides the specification
of cell fates, the movement of cells within and between tissues, and the coordinated …
of cell fates, the movement of cells within and between tissues, and the coordinated …
To not love thy neighbor: mechanisms of cell competition in stem cells and beyond
M Yusupova, Y Fuchs - Cell Death & Differentiation, 2023 - nature.com
Cell competition describes the process in which cells of greater fitness are capable of
sensing and instructing elimination of lesser fit mutant cells. Since its discovery in …
sensing and instructing elimination of lesser fit mutant cells. Since its discovery in …
Cell competition: mechanisms and physiological roles
C Clavería, M Torres - Annual review of cell and developmental …, 2016 - annualreviews.org
Cell-competitive interactions are widespread in nature and determine the outcome of a vast
variety of biological processes. A particular class of competitive interactions takes place …
variety of biological processes. A particular class of competitive interactions takes place …
[HTML][HTML] Cell competition: A historical perspective
G Morata - Developmental Biology, 2021 - Elsevier
Cell competition is a homeostatic process designed to remove from animal tissues viable
cells that are unfit, abnormal or malignant and that may compromise the general fitness or …
cells that are unfit, abnormal or malignant and that may compromise the general fitness or …