Cell competition: emerging signaling and unsolved questions

R Nagata, T Igaki - FEBS letters, 2024 - Wiley Online Library
Multicellular communities have an intrinsic mechanism that optimizes their structure and
function via cell–cell communication. One of the driving forces for such self‐organization of …

Cell competition: how to eliminate your neighbours

M Amoyel, EA Bach - Development, 2014 - journals.biologists.com
A conventional view of development is that cells cooperate to build an organism. However,
based on studies of Drosophila, it has been known for years that viable cells can be …

[HTML][HTML] Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α

N Ochi, M Nakamura, R Nagata, N Wakasa… - PLoS …, 2021 - journals.plos.org
Cell competition is a context-dependent cell elimination via cell-cell interaction whereby unfit
cells ('losers') are eliminated from the tissue when confronted with fitter cells ('winners') …

Picking winners and losers: cell competition in tissue development and homeostasis

W Kim, R Jain - Trends in Genetics, 2020 - cell.com
Viable cells with reduced fitness are often eliminated by neighboring cells with greater
fitness. This phenomenon, called cell competition, is an important mechanism for …

Loss of Rer1 causes proteotoxic stress that drives cell competition and inhibits Myc-driven overgrowth

PK Paul, W Annaert, V Chaudhary - bioRxiv, 2022 - biorxiv.org
Cell competition is a developmental phenomenon that allows the selection of healthier cells
in a developing tissue. In this process, cells with reduced fitness, conceivably due to harmful …

Emerging mechanisms of cell competition

NE Baker - Nature Reviews Genetics, 2020 - nature.com
The growth and survival of cells within tissues can be affected by 'cell competition'between
different cell clones. This phenomenon was initially recognized between wild-type cells and …

New frontiers in cell competition

S de Beco, M Ziosi, LA Johnston - Developmental dynamics, 2012 - Wiley Online Library
Cellular communication is at the heart of animal development, and guides the specification
of cell fates, the movement of cells within and between tissues, and the coordinated …

To not love thy neighbor: mechanisms of cell competition in stem cells and beyond

M Yusupova, Y Fuchs - Cell Death & Differentiation, 2023 - nature.com
Cell competition describes the process in which cells of greater fitness are capable of
sensing and instructing elimination of lesser fit mutant cells. Since its discovery in …

Cell competition: mechanisms and physiological roles

C Clavería, M Torres - Annual review of cell and developmental …, 2016 - annualreviews.org
Cell-competitive interactions are widespread in nature and determine the outcome of a vast
variety of biological processes. A particular class of competitive interactions takes place …

[HTML][HTML] Cell competition: A historical perspective

G Morata - Developmental Biology, 2021 - Elsevier
Cell competition is a homeostatic process designed to remove from animal tissues viable
cells that are unfit, abnormal or malignant and that may compromise the general fitness or …